Kanamikan-P

Therapeutic indications:

KANAMIKAN-P is used for the treatment of acute mastitis in cows, goats, sheep.

Composition of the veterinary drug:

The 10 g of the drug contains:

•          100. 000 IU of kanamycin sulfate (equivalent to 133 mg kanamycin sulfate);

•          300. 000 IU of procaine benzylpenicillin (equivalent to 288 mg);

•          20 mg of prednisolone;

Pharmacological activity:

Kanamycin sulfate is aminoglycoside antibiotic, which has a bactericidal effect on many gram-positive and gram-negative microorganisms, including: Escherichia coli, Proteus spp., Salmonella spp., Staphylococcus spp., Campylobacter spp.  and other.  It is less active against streptococci and gram-negative cocci.  The resistance of microorganisms to kanamycin develops slowly and to a minor extent.

The mechanism of kanamycin action is based on binding to the 30S subunit of bacterial ribosomes and inhibition of the protein biosynthesis.

The active substance of the drug is procaine benzylpenicillin, a long-acting antibiotic of the penicillin group with a narrow spectrum of bactericidal action.  Procaine benzylpenicillin is predominantly effective against gram-positive microorganisms, such as: Staphylococcus spp., Streptococcus spp., Corynebacterium spp.  and etc.

Procaine benzylpenicillin inhibits the synthesis of acetylmuramic acid, that is required for building a bacterial cell wall.

Prednisolone has anti-inflammatory and anti-allergic effects, reduces udder swelling and inflammation.  Prednisolone does not have an adverse effect on the activity of white blood cells (WBC) in the inflammation area and increases the penetration of antibiotics into tissues.

When administered via intramammary injection, the active substances of the drug are quickly distributed in mammary gland tissues and absorbed into the bloodstream to an insignificant extent.  The drug is excreted from the body mainly with the urine, partly with the bile.

Dosage:

Before drug administration, milk out the treated udder quarters; clean and disinfect the nipples. Carefully put is the tip of the syringe in the nipple canal and squeeze out the syringe content. If necessary, heat the syringe up to the animal's body temperature.

The drug is administered intracisternally to cows in a dose of 10 g (1 syringe), goats and sheep - in a dose of 5 g (1/2 syringe) in each affected udder lobe at intervals of 12-24 hours. in a dose of 5 g (1/2 syringe) in each affected udder lobe with an interval of 12-24 hours, 3-6 injections depending on severity of inflammatory process. After administration of the drug the syringe tip is removed, the tip of the teat is squeezed with fingers and lightly massage the teat from bottom to top for better distribution of the drug. upward for better distribution of the drug. The interval between the introduction of the drug and the following drinking should be at least 6 hours.

Precautions and adverse reactions:

When the drug is used in recommended doses and in accordance with all the instructions, side effects and complications are generally not observed. In case of allergic reaction, the drug should be cancelled; antihistamines, calcium should be prescribed.

No overdose symptoms have been revealed.

After the first administration and cancellation, no peculiarities of the drug use are revealed.

If administration of the veterinary drug is missed, resume it in the same dosage and according to the same treatment scheme.

Contraindications:

Do not use in animals with hypersensitivity to the components of the drug.

Do not use the drug simultaneously with macrolide, tetracycline, polymyxin and lincosamide antibiotics.

Withdrawal period:

Animals must not be slaughtered for human consumption before 4 days after the last drug administration. Meat of animals forcibly slaughtered earlier than the specified period expires may be used to feed carnivores.

It is forbidden to use milk for human consumption during the treatment period and within 3 days after the last drug administration providing complete clinical recovery. Boiled mIlk obtained before the specified period expires may be used for feeding animals. 

Storage conditions:

Store in a dark place at a temperature between + 2 ° C to + 25 ° C.

Shelf-life:

Shelf-life of the veterinary drug is 2 (two) years from the date of manufacture under appropriate storage conditions. After opening, use immediately.