Recefur

Therapeutic indications:

The drug is used for the treatment of cattle, sheep, goats, and pigs for respiratory and gastrointestinal diseases; for necrobacillosis in cattle and sheep; for sepsis, pyelonephritis, arthritis, endometritis, metritis, mastitis, and other diseases caused by microorganisms sensitive to ceftiofur.

Pharmacotherapeutic group:

Cephalosporins.

Dosage form description

Suspension for intramuscular and subcutaneous administration. In appearance, the drug is a light yellow to brown suspension.

Colorless or dark glass vials of 100 ml.

Composition of the veterinary drug:

1 ml of the drug contains 50 mg of ceftiofur (as ceftiofur hydrochloride) as the active substance.

Pharmacological activity:

Ceftiofur, which is part of the drug, has a broad spectrum of action against gram-positive and gram-negative microorganisms, including: Streptococcus spp., Trueperella (Actinomyces) pyogenes, Staphylococcus spp., Salmonella spp., Escherichia coli, Mannheimia haemolytica, Pasteurella multocida, Histophilus somni (Haemophilus somnus), Actinobacillus pleuropneumoniae, Haemophilus parasuis, Klebsiella spp., Citrobacter spp., Enterobacter spp., Bacillus spp., Proteus spp., Fusobacterium necrophorum, and Bacteroides melaninogenicus (Prevotella melaninogenica), including lactamase-producing strains.

The mechanism of action of ceftiofur consists in inhibiting the transpeptidase enzyme and disrupting the synthesis of peptidoglycan, a mucopeptide (murein) of the cell wall, which leads to impaired growth of the microorganism's cell wall and bacterial lysis.

After administration of the drug, ceftiofur is rapidly metabolized to form desfuroylceftiofur, which has equivalent activity against bacteria as ceftiofur. The active metabolite reversibly binds to blood plasma proteins and concentrates in tissues affected by the pathogen. The maximum concentration of ceftiofur and its metabolites in the blood is reached within 0.5–2 hours and is maintained at a therapeutic level for up to 24 hours from the moment of drug administration, while the activity of the drug is not reduced in the presence of necrotic tissues. Ceftiofur and its metabolites are excreted from the animal body primarily with urine.

Dosage:

The drug is administered to cattle intramuscularly or subcutaneously at a dose of 1 ml of the drug per 50 kg of animal body weight (which corresponds to 1 mg of ceftiofur per 1 kg of animal body weight).

In necrobacillosis, the course of treatment lasts 3 days; in postpartum endometritis (metritis), 5 days (in the first 10 days after calving); in respiratory tract diseases, 3–5 days.

To young cattle, sheep, and goats, the drug is administered intramuscularly or subcutaneously at a dose of 0.3 ml per 10 kg of animal body weight (which corresponds to 1.5 mg of ceftiofur per 1 kg of animal body weight), but no more than 5 ml at one injection site. Treatment is carried out for 3–5 days.

To pigs, the drug is administered intramuscularly at the rate of 1 ml of the drug per 16 kg of animal body weight (which corresponds to 3 mg of ceftiofur per 1 kg of animal body weight) for 3 days.

Before each use, the vial with the drug is thoroughly shaken until a homogeneous suspension is obtained.

Contraindications:

Contraindicated for use in animals with hypersensitivity to the components of the drug.

Overdose:

In case of overdose of the drug in the animal, a decrease in appetite and swelling at the injection site may be observed, which disappear spontaneously.

Pregnancy and lactation:

Peculiarities of the drug's use in females during pregnancy and lactation have not been established.

Special indications:

No special features of action upon the first application of the drug or upon its withdrawal have been identified. Skipping a scheduled application of the drug to animals should be avoided, as this may lead to a decrease in therapeutic efficacy. If administration of the drug is missed, the course of application must be resumed in accordance with the prescribed dose and treatment regimen. The missed application of the drug should not be compensated for by increasing the dose.

Side effects and individual intolerance:

Side effects and complications when using the drug in accordance with this instruction are generally not observed. In animals with hypersensitivity to the components of the drug, allergic reactions (dyspnea, hyperemia, pruritus, edema) may manifest. In this case, the use of the drug is discontinued, and antihistamines and calcium preparations are prescribed if necessary.

Withdrawal period:

Slaughter of cattle for meat is allowed no earlier than 8 days, and of pigs, sheep, and goats no earlier than 5 days after applying the drug. In case of forced slaughter of animals earlier than the specified period, the meat can be used for feeding carnivorous animals. Milk from cattle and small ruminants after using the drug can be used for food purposes without restrictions.

Shelf-life:

18 months from the date of manufacture. It is forbidden to use the drug after the expiration date.

Storage conditions:

In a place protected from light at a temperature from 2 °C to 25 °C. The drug should be stored in a place inaccessible to children. After the first opening of the vial, 28 days subject to storage conditions.