Retsefur

Therapeutic indications:

The drug is used in cattle, sheep, goats and pigs for the treatment of respiratory and gastrointestinal diseases; as well as for the treatment of necrobacteriosis of cattle and sheep; sepsis, pyelonephritis, arthritis, endometritis, metritis, mastitis and other diseases caused by microorganisms sensitive to ceftiofur.

Composition of the veterinary drug:

1 ml of the drug contains:

•          50 mg of ceftiofur in a form of ceftiofur hydrochloride as an active substance.

Pharmacological activity:

Antibiotic ceftiofur, which is the active substance of the drug, belongs to the cephalosporin group and has a broad spectrum of action against gram-positive and gram-negative bacteria, including Streptococcus spp., Actinomyces pyogenes, Staphylococcus spp., Salmonella spp., Escherichia coli, Mannheimia haemolytica, Pasteurella multocida, Histophilus somni (Haemophilus somnus), Actinobacillus pleuropneumoniae, Haemophilus parasuis, Klebsiella spp., Citrobacter spp., Enterobacter spp., Bacillus spp., Proteus spp., Fusobacterium necrophorum and Bacteroides melaninogenicus (Prevotella melaninogenica), including strains producing β-lactamase.

Ceftiofur inhibits the enzyme transpeptidase and suppresses the synthesis of mucopeptide (murein), peptidoglycan of the cell wall, that leads to the impaired growth of the microorganism’s cell wall and bacterial lysis.

After the drug administrartion, ceftiofur is rapidly metabolized to form desfuroylceftiofur, which has the same bactericidal activity as ceftiofur.  This active metabolite reversibly binds to proteins and is accumulated by the tissues affected by the pathogen. The maximum concentration of ceftiofur and its metabolites in the blood is reached in 0,5—2 hours and is maintained at therapeutic level for up to 24 hours from the moment of the drug administration. Decreased activity of ceftiofur in the presence of necrotic tissues is not observed. Ceftiofur and its metabolites are excreted from the animal body mainly with urine.

Dosage:

The drug is given to cattle via intramuscular or subcutaneous injection at the dose of 1 ml of the drug per 50 kg of body weight (which corresponds to 1 mg of ceftiofur per 1 kg of body weight).  For the treatment of necrobacteriosis use the drug for 3 days; in the case of endometritis (metritis) - 5 days (in the first 10 days after calving); diseases of the respiratory tract - 3-5 days.

The drug is given to young cattle, sheep and goats via intramuscular or subcutaneous injection at the dose of 0.3 ml per 10 kg of body weight (which corresponds to 1.5 mg of ceftiofur per 1 kg of body weight). Do not inject more than 5 ml per injection site.  The treatment is carried out within 3-5 days.

The drug is administered intramuscularly to pigs at a dose of 1 ml of the drug per 16 kg of body weight (which corresponds to 3 mg of ceftiofur per 1 kg of body weight) for 3 days.

Before each use, the vial with the drug is thoroughly shaken until a homogeneous suspension is obtained.

Precautions and adverse reactions:

If used in accordance with the instructions, the drug usually does not cause side effects. In animals and poultry with increased individual sensitivity, allergic reactions may occur (shortness of breath, hyperemia, itching, swelling). In this case, the use of the drug is discontinued; if necessary, antihistamines and calcium preparations are prescribed.

Do not use in animals with hypersensitivity to the components of the drug.

In case of an overdose of the drug, the animal may show a decrease in appetite, swelling at the injection site, disappearing spontaneously.

Do not use the drug simultaneously with tetracycline, macrolide, lincosamide antibiotics. Do not mix with other drugs in the same syringe.

After the first administration and cancellation, no peculiarities of the drug use have been revealed.

Avoid missing the next dose of the drug, as it may lead to the reduced therapeutic effect. If administration of the veterinary drug is missed, resume it in the same dosage and according to the same treatment scheme as soon as possible. Do not increase the dose to compensate the missing one.

No peculiarities of the drug use have been revealed in lactating females.

Withdrawal period:

Cattle should not be slaughtered for human consumption within 8 days, sheep, goats and pigs – 5 days after the last drug treatment. Meat of animals forcibly slaughtered earlier than the specified period expires may be used for feeding carnivores.

Milk obtained from cattle and ruminant animals may be used for human consumption without any restrictions after the last drug administration.

Storage conditions:

Store in a dry, dark place at a temperature between 2 ° C to 25 ° C. The drug should be kept out of the reach of children.

Shelf-life:

Shelf-life of the veterinary drug is 18 months from the date of manufacture. Shelf-life after the first opening is 28 days under appropriate storage conditions.