Recefur PS-200

Therapeutic indications:

The drug is used in cattle for the treatment of respiratory (BRD) and gastrointestinal diseases, necrobacteriosis, sepsis, pyelonephritis, arthritis, endometritis, metritis, mastitis; in pigs with respiratory and gastrointestinal diseases, metritis-mastitis-agalactia; in cattle and pigs with other diseases caused by ceftiofur-sensitive microorganisms. 

Composition of the veterinary drug:

1 ml of the drug contains:

•             200 mg of ceftiofur crystalline-free acid as an active substance.

Pharmacological activity:

Ceftiofur is a third-generation antibiotic of the cephalosporin group. Ceftiofur, which is the active substance of the drug, has a broad spectrum of action against gram-positive and gram-negative bacteria, including Streptococcus spp., Actinomyces pyogenes, Staphylococcus spp., Salmonella spp., Escherichia coli, Pasteurella spp., Haemophilus spp., Klebsiella spp., Citrobacter spp., Enterobacter spp., Bacillus spp., Proteus spp., Fusobacterium necrophorum and Bacteroides melaninogenicus (Porphiromonas assacharolytica), including strains producing β-lactamase.

Ceftiofur inhibits the enzyme transpeptidase and suppresses the synthesis of mucopeptide (murein), peptidoglycan of the cell wall, that leads to the impaired growth of the microorganism’s cell wall and bacteria lysis.

After the drug administrartion, ceftiofur is rapidly metabolized to form desfuroylceftiofur, which has bactericidal activity equivalent to ceftiofur.  This active metabolite reversibly binds to proteins and is accumulated in the tissues affected by the pathogen. The maximum concentration of ceftiofur and its metabolites in the blood is reached in 12 hours and is maintained at a therapeutic level for up to 7 days from the moment of the drug administration. Decreased activity of ceftiofur in the presence of necrotic tissues is not observed.  Ceftiofur and its metabolites are excreted from the animal body mainly with urine.

Dosage:

The drug is administered to:

• cattle via subcutaneous injection at the base of the ear at a single dose of 1.0 ml of the drug per 30 kg of body weight, which corresponds to 6.67 mg of ceftiofur per 1 kg of animal body weight.  Do not inject more than 20 ml per one injection site.
• pigs via a single intramuscular injection at a dose of 0.5 ml of the drug per 20 kg of animal body weight, which corresponds to 5 mg of ceftiofur per 1 kg of animal body weight. It is recommended to inject no more than 4 ml of the drug into one injection site. 

Before using flask with the drug should be shaken until a homogeneous suspension is obtained.

Precautions and adverse reactions:

When the drug is used in recommended doses and in accordance with all the instructions, side effects and complications are generally not observed.In rare cases, in cattle, a swelling may form at the injection site, which disappears naturally; in pigs, swelling and alopecia area may form at the injection site, which naturally disappear within 55 days.

Do not use in animals with hypersensitivity to β-lactam antibiotics. If symptoms of an allergic reaction occur, the drug should be cancelled; antihistamines, preparations with calcium should be prescribed.

No overdose symptoms have been revealed.

Do not use the drug simultaneously with tetracycline, macrolide, lincosamide antibiotics. Do not mix with other drugs in the same syringe.

The drug may be used in in pregnant and lactating cows under the supevision of a veterinarian.

Withdrawal period:

Cattle should not be slaughtered for human consumption within 20 days after the last drug treatment, pigs - not earlier than 71 days after the last drug treatment. Meat of animals forcibly slaughtered earlier than the specified period expires may be used for feeding carnivores. Milk obtained from cattle may be used for human consumption without any restrictions after the drug administration.

Storage conditions:

Store in a dark place at a temperature between 2 ° C to 25 ° C. The drug should be kept out of the reach of children.

Shelf-life:

Shelf-life of the veterinary drug is 2 years from the date of manufacture. Shelf-life after the first oppening is 28 days.