Streppen LA

Therapeutic indications:

STREPPEN LA is used in cattle, pigs, sheep, goats for the treatment of arthritis, mastitis; gastrointestinal, respiratory and urogenital infections caused by benzylpenicillin and dihydrostreptomycin-sensitive microorganisms.

Composition of the veterinary drug:

1 ml of the drug contains:

• 100, 000 IU of procaine benzylpenicillin,
• 100, 000 IU of benzathine benzylpenicillin,
• 200 mg of dihydrostreptomycin sulfate as the active substances of the drug.

Pharmacological activity:

STREPPEN LA is a complex long-acting antibacterial drug. Combination of benzylpenicillins and dihydrostreptomycin sulfate, which are the active substances of the drug, results in intensified antibacterial action and extended spectrum of antimicrobial activity..

Procaine benzylpenicillin and benzathine benzylpenicillin are antibiotics of the β-lactam group. These antibiotics have bactericidal activity against gram-positive and gram-negative bacteria such as Clostridium spp., Corynebacterium spp., Erysipelothrix rhusiopathiae (insidiosa), Listeria monocytogenes, Streptococcus spp. Procaine benzylpenicillin and benzathine benzylpenicillin are highly effective against non-penicillinase-producing bacteria: Staphylococcus spp., Leptospira spp., Treponema spp.

Procaine benzylpenicillin and benzathine benzylpenicillin bind to penicillin-binding proteins (PBPs) of the bacterial cell wall and suppress the peptidoglycan synthesis, that leads to the impaired growth of the microorganism’s cell wall and further bacterial lysis.

Dihydrostreptomycin sulfate is an antibiotic of the aminoglycoside group, which is active against gram-negative bacteria, including Escherichia coli, Salmonella spp., Pasteurella spp., Leptospira spp., Klebsiella spp., Campylobacter spp., Haemophilus spp.

Dihydrostreptomycin sulfate binds to the 30S subunit of bacterial ribosomes, that leads to the incorporation of erroneous amino acids into the growing polypeptide chain and the synthesis of non-functional proteins in the bacterial cell.

Being administered via intramuscular injection, procaine benzylpenicillin, benzathine benzylpenicillin and dihydrostreptomycin sulfate are slowly absorbed. The therapeutic concentration of the active substances of the drug is maintained in the organism for 72 hours. The drug is excreted from the organism mainly with urine.

Dosage:

The drug is administered via intramuscular injection to:

·       cattle - at a dose of 1.0 ml of the drug per 20 kg of animal body weight. Do not inject more than 20 ml of the drug per one injection site.

·       pigs - at a dose of 1.0 ml of the drug per 20 kg of animal body weight. Do not inject more than 10 ml of the drug per one injection site.

·       calves, piglets, sheep, goats - at a dose of 1.0 ml of the drug per 10 kg of animal body weight. Do not inject more than 5 ml of the drug per one injection site.

If necessary, the injection of the drug is repeated after 72 hours.

Before using the drug, the flask should be shaken thoroughly. 

Precautions and adverse reactions:

When using the drug, side effects, such as premature parturition in sows, ototoxicity, neurotoxicity, nephrotoxicity and allergic reactions may be observed. If side effects occur, the drug should be cancelled. If symptoms of an allergic reaction occur, antihistamines and preparations with calcium should be prescribed.

No overdose symptoms when using the drug have been observed.

Do not use in animals with hypersensitivity to penicillins and/or aminoglycosides, as well as in animals with impaired renal excretory function.

Do not use the drug simultaneously with other antibiotics which has oto- and nephrotoxic effects (neomycin, kanamycin, monomycin, gentamicin and others).  Do not use the drug simultaneously with antibiotics of the macrolide groups, as well as with tetracycline, polymyxin and lincosamide antibiotics. 

Withdrawal period:

Animals should not be slaughtered for human consumption within 30 days after the last treatment. It is forbidden to use kidneys for human consumption during the treatment period and within 45 days after the last drug administration. Meat and kidneys of animals forcibly slaughtered earlier than the specified period expires may be used for feeding carnivores.

It is forbidden to use milk for human consumption during the treatment period and within 7 days after the last drug administration. Milk obtained before the expiry of the established period is allowed for animal feeding after thermal treatment.

Storage conditions:

Store in a dark place at a temperature between +2 °C to +25 °C. After the first opening of the bottle, the drug is stored at a temperature between +2 °C to +8 °C.

The drug should be kept out of reach of children.

Shelf-life:

Shelf-life of the veterinary drug is 1 year from the date of manufacture. Shelf-life after the first opening of the bottle is 14 days under appropriate storage conditions. Do not use the drug after the expiry date. Unused veterinary drug should be utilized in accordance with the requirements of the law.