AmoxyBAG

Veterinary drug AmoxyBAG


For use in infectious diseases of cattle, pigs, dogs and cats



  • Broad spectrum of activity

  • High stability of active substances in animal body

  • Effective in the treatment of infections of various organs and tissues

  • Effective against secondary infections caused by stress and complications

  • Fast-acting (maximum plasmatic levels reached in an 1 hour)

  • Antibacterial activity lasts for 48 hours



 

Therapeutic indications:

Veterinary drug AmoxyBAG is used in cattle, pigs, dogs and cats to treat bacterial diseases of the respiratory system, gastrointestinal tract, genitourinary system, soft tissues and skin (abscesses, phlegmon, pyoderma, inflammation of the paraanal glands, gingivitis), as well as for postoperative and postpartum infections, mastitis secondary bacterial infections and other infectious diseases caused by microorganisms sensitive to the components of the drug.

Composition of the veterinary drug:

1 ml AmoxyBAG suspension for injection contains:

  • Amoxicillin 140 mg
  • Clavulanic acid 35 mg

Pharmacological activity:

The veterinary drug AmoxyBAG is a combination of amoxicillin and clavulanic acid. Active substances of the veterinary drug have synergistic effect, enhancing each other’s activity and expanding the spectrum of antimicrobial activity. The veterinary drug has a broad spectrum of bactericidal activity against most gram-positive and gram-negative bacteria, including ß-lactamase-producing strains.

Amoxicillin is a semi-synthetic antibiotic from the group of penicillins, has a broad spectrum of activity, and is active against gram -positive and gram -negative bacteria. It is a 4-hydroxy analog of ampicillin. Amoxicillin has multiple effects, inhibiting transpeptidase and blocking the synthesis of peptidoglycan of the cell wall (basic protein of the cell wall) during the period of division and growth of the bacteria, thereby causing the lysis of bacteria.

The clavulanic acid salt that compose the veterinary drug has weak antibacterial activity, but irreversibly binds β-lactamases (forms a stable complex with them), protecting amoxicillin from enzymatic destruction and restoring the sensitivity of bacteria to the bactericidal activity of amoxicillin in concentrations that are easily achieved in animal tissues after administration of the veterinary drug, providing a guaranteed possibility of manifestation of its antibacterial effect.

By an intramuscular administration, the veterinary drug is quickly absorbed into the blood and penetrates into all organs, tissues and body fluids. The maximum blood concentration is recorded after 1 hour and maintained at a therapeutic level for up to 48 hours.

The active substances of the veterinary drug easily penetrate into most tissues and body fluids; accumulate in therapeutic concentrations in peritoneal fluid, urine, pleural effusion, lung tissue, intestinal mucosa, genitals, middle ear fluid, gall bladder and bile (by normal liver function), fetal tissues, muscles, bones, skin.

The veterinary drug is partially metabolized into an inactive form. 50-70% is excreted by kidneys in unchanged form by tubular secretion (80%) and glomerular filtration (20%),10-20% - by liver. A small amount is excreted in milk.

Dosage:

The veterinary drug is administered once daily for 3 to 5 days, in the following doses:

  • cattle and pigs - 1 ml /20 kg body weight, only by intramuscular injection, but no more than 15 ml should be injected in a single injection site;
  • dogs and cats - 0.1 ml /2 kg body weight, by intramuscular or subcutaneous injection, but no more than 2 ml should be injected in a single injection site.

Precautions and adverse reactions:

In recommended doses, the veterinary drug can sometimes cause allergic reactions. In case of their occurrence AmoxyBAG is cancelled, antihistamines and calcium preparations are prescribed.

Do not use in animals which are known to be hypersensitive to to amoxicillin and other penicillins, as well as to antibiotics from the cephalosporin group. 

The drug may be used in pregnant and lactating females, as well as for newborn animals followed by a veterinarian's recommendation.

In case of an overdose, the animal may experience refusal of food, vomiting, impaired coordination of movements.

No specific features of the drug's action during the first use and cancellation have been identified.

If the drug is missed, the use must be resumed as soon as possible in accordance with the prescribed dosage and treatment regimen. Do not increase the dose to compensate for the missed one.

Combined use of the drug with bacteriostatic chemotherapeutic agents is not allowed.

Withdrawal period:

Animals must not be slaughtered for human consumption within 14 days after the last treatment. Meat of animals forcibly slaughtered earlier than the specified period may be used for feeding carnivores. Milk for human consumption may only be taken after 3 days from the last treatment. Until the specified period expires, milk may be used after heat treatment for feeding carnivores.

Storage conditions:

Store in a dry, dark place at a temperature of +2C to +25C.

Shelf-life:

Shelf-life of the veterinary drug under appropriate storage conditions is 2 years from the date of manufacture. Shelf-life after first opening: 14 days.

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