BAG-Estrofan

Therapeutic indications:

BAG- Estrofan is indicated for cows and heifers for synchronization of estrus; for treatment of luteal or follicular ovarian cysts, and persistent corpus luteum in cows; for treatment of postpartum endometritis and uterine subinvolution in cows; for treatment or prevention of functional ovarian disorders in sows; for induction and synchronization of farrowing in sows; for prevention or treatment of incomplete cervical dilation in sheep; for termination of pregnancy.

Composition of the veterinary drug:

1 ml BAG- Estrofan solution for injection contains:

Cloprostenol 0.25 mg (in a form of cloprostenol sodium) as an active compound

Pharmacological activity:

Cloprostenol is an active substance of the veterinary drug. Cloprostenol is the synthetic analog of Prostaglandin F 2a (PGF2a), which is involved in the regulation of estrous cycle.

BAG- Estrofan causes luteolysis of the corpus luteum in ovaries, reduces the inhibitory effect of progesterone on the hypothalamic-pituitary axis, which contributes to the growth of follicles in ovaries, as well as an increase of estrogen level in blood and induction of estrus and subsequent ovulation of mature follicles. The period from the administration of the veterinary drug to the first signs of estrus is 48-96 hours.

The veterinary drug enhances the contractile function of the uterus and exhibits a biological effect only if there is an active corpus luteum in ovaries.

Dosage:

The veterinary drug is administered by intramuscular injection in the following doses:

• For synchronization of estrus in cows and heifers: double dose of 2 ml is administered at 10 days intervals;
• For treatment of ovarian luteal cysts in cows: single dose of 4 ml is administered; or double dose of 2 ml is administered at 24 hours intervals;
• For treatment of ovarian follicular cysts in cows: single dose of 4 000-5 000 IU of chorionic gonadotropin is administered by subcutaneous injection, or 5 ml of surfagon is administered by intramuscular injection, for 3 days. Then single dose of 2 ml of BAG- Estrofan is administered 10-12 days after administration of chorionic gonadotropin or surfagon for animals that show no signs of estrus;
• For treatment of persistent corpus luteum in cows: single dose of 2 ml is administered;
• For treatment of postpartum endometritis and uterine subinvolution in cows: double dose of 2 ml is administered at 10-11 days intervals;
• For recovery of reproductive performance in sows: single dose of 1 ml is administered in combination with either of the gonadotropic veterinary drugs for sows that show no signs of estrus within 12 days after weaning of pigs;
• For synchronization of farrowing and prevention postpartum diseases in sows: single dose of 0.7 ml is administered on 113-114 days of gestation;
• For treatment and prevention of incomplete cervical dilation in sheep: single dose of 2 ml is administered 15-16 days before the intended lambing;
• For termination of pregnancy: single dose of 2 ml is administered. 

Precautions and adverse reactions:

Do not administer to pregnant animals unless the objective is the termination of pregnancy or induction of parturition; and also to animals which are known to be hypersensitive to cloprostenol.

Increased heart rate and breathing, bronchospasm, increased rectal temperature, increased bowel movements and urination, salivation and vomiting may occur in case of the overdose of the veterinary drug. These symptoms usually disappear spontaneously without the intervention of a veterinarian.

If administration of the veterinary drug is missed, resume it in the same dosage according to the same scheme as soon as possible.

Do not use simultaneously with veterinary drugs, that contain hydrocyanic acids and alkalis.

Simultaneous administration of the veterinary drug with oxytocin increases the effect on the uterus.

Withdrawal period:

Animals must not be slaughtered for human consumption within 1 day after the last treatment. Meat of animals forcibly slaughtered earlier than the specified period may be used for feeding carnivores. Milk for human consumption may be taken without limits.

Storage conditions:

Store in a dry dark place at a temperature of +2C to +25C. Keep out of reach of children.

Shelf-life:

Shelf-life of the veterinary drug under appropriate storage conditions is 2 years from the date of manufacture. Shelf-life after first opening: 28 days.