BAG-Estrofan

Therapeutic indications:

BAG- Estrofan is used in cows and heifers for synchronization of estrus; for treatment of luteal or follicular ovarian cysts, and persistent corpus luteum in cows; for treatment of postpartum endometritis and uterine subinvolution in cows; for treatment or prevention of functional ovarian disorders in sows; for induction and synchronization of farrowing in sows; for prevention or treatment of incomplete cervical dilation in sheep; for termination of pregnancy (for medical reasons).

Composition of the veterinary drug:

1 ml of BAG- Estrofan contains:

0.25 mg of  cloprostenol (in a form of cloprostenol sodium) as an active compound

Pharmacological activity:

Cloprostenol is an active substance of the veterinary drug. Cloprostenol has a luteolytic (resorbing) effect on the corpus luteum and luteal ovarian cysts, relieves the inhibitory effect of progesterone on the hypothalamic-pituitary complex, which promotes the growth of follicles in the ovaries, elevates estrogens level in the blood, manifestate estrus, hunting and subsequent ovulation of mature follicles. The period from administration of the drug to the first signs of sexual hunting is 48-96 hours.

The drug enhances the contractile function of the uterus and exhibits a biological effect only in the presence of actively functioning yellow bodies in the ovaries.

After intramuscular administration, cloprostenol is well absorbed from the injection site. The peak level of cloprostenol in the blood plasma of animals is observed within 15-120 minutes. In animals, cloprostenol is rapidly metabolized and excreted within 24 hours after administration, mainly in urine and faeces.

Dosage:

The veterinary drug is administered by intramuscular injection in the following doses:

• Synchronization of estrus in cows and heifers: 2 ml of the drug is administered twice with an interval of 10-11 days. The first dose of the drug is administered at any phase of the sexual cycle (in cows from 40 to 60 days after calving). In the absence of an arousal stage, a second dose should be administered on the eleventh day after the first administration, and on the fourteenth day (72-76 hours after the second administration) frontal artificial insemination (regardless of external signs of sexual hunting) is performed with repeated insemination on the fifteenth day.;
• Treatment of ovarian luteal cysts in cows: the drug is administered once in a dose of 4 ml or twice with an interval of 24 hours in a dose of 2 ml of the drug. To increase the therapeutic effectiveness, the drug is administered in the same dose with subcutaneous injection of gonadotropin SFM (serum of foaled mares) at a dose of 2.5–3 thousand mouse units (M.E.);
• Treatment of ovarian follicular cysts in cows: cows are subcutaneously injected with chorionic gonadotropin once at a dose of 4-5 thousand units or "BAG-Surfagon" intramuscularly 5 ml for three days. After 10-12 days, the drug is injected into animals that have not come to hunt in a dose of 2 ml.
• Treatment of persistent corpus luteum in cows: the drug is administered in a dose of 2 ml, and artificial insemination is carried out at the first signs of sexual hunting. If it does not occur, then 2 ml of the drug should be re-administered on the eleventh day after the first injection, followed by insemination after 72-76 hours according to the instructions;
• Treatment of postpartum endometritis and uterine subinvolution in cows: the drug is administered twice with an interval of 10-11 days for 2 ml with simultaneous administration of etiotropic, pathogenetic and symptomatic therapy;
• Recovery of reproductive performance in sows that did not show hunting within 12 days after weaning piglets, the drug is administered in a dose of 1 ml in combination with one of the gonadotropins in accordance with the current instructions;
• Synchronization of farrowing and prevention postpartum diseases in sows: the drug is administered in a dose of 0.7 ml on the 113-114 day of pregnancy. Farrowing occurs in most cases after 24-35 hours;
• Treatment and prevention of incomplete cervical dilation in sheep: for pregnant sheep, the drug is administered in a dose of 2 ml 15-16 days before the expected lambing. In case of vaginal prolapse 3-5 days before delivery, the drug is administered once at the above dose as part of complex therapy;
• Termination of pregnancy: is achieved by administering the drug in the following doses: cows – 2 ml, sows and sheep – 0.7 ml. 

Precautions and adverse reactions:

When used in accordance with the instruction, side effects and complications are generally not observed. In animals with increased individual sensitivity to the components of the drug, allergic reactions may occur. In this case, the drug should be cancelled; and, if necessary, antihistamines and symptomatic treatment should be prescribed.

Do not use in animals with increased individual sensitivity to the components of the drug.

In case of the overdose of the veterinary drug, increased heart rate and breathing, bronchospasm, increased rectal temperature, increased bowel movements and urination, salivation and vomiting may occur. These symptoms usually disappear spontaneously without the intervention of a veterinarian.

After the first administration and cancellation, no peculiarities of the drug use are revealed.

Do not use simultaneously with veterinary drugs, that contain hydrocyanic acids and alkalis. Simultaneous administration of the veterinary drug with oxytocin increases the effect on the uterus.

Avoid missing the next dose of the drug, as it may lead to the reduced therapeutic effect. If administration of the veterinary drug is missed, resume it in the same dosage and according to the same treatment scheme as soon as possible. Do not increase the dose to compensate the missing one.

Do not administer to pregnant animals unless the objective is the termination of pregnancy or induction of parturition.

Withdrawal period:

Animals must not be slaughtered for human consumption within 1 day after the last treatment. Meat of animals forcibly slaughtered earlier than the specified period may be used for feeding carnivores. Milk for human consumption may be taken without limits.

Storage conditions:

Store in a dry dark place at a temperature of 2°C to 25°C. Keep out of reach of children.

Shelf-life:

Shelf-life of the veterinary drug under appropriate storage conditions is 2 years from the date of manufacture. Shelf-life after first opening: 28 days.