BAG-Surfagon

Therapeutic indications:

BAG- Surfagon is indicated for cattle for induction of estrous cycle, prevention of perinatal mortality, induction of superovulation in donor cows, improvement of fertility, and for treatment of ovarian hypofunction and ovarian follicular cysts; for pigs and sheep for induction of estrous and improvement of fertility.

Composition of the veterinary drug:

1 ml BAG- Surfagon solution for injection contains:

Surfagon 5 microgram as an active compound

Pharmacological activity:

The active substance of the veterinary drug is synthetic surfagon oligopeptide, which is an analog of the gonadotropin-releasing hormone or luliberin (LH-RH). Upon parenteral administration pharmacological activity of BAG- Surfagon is identical to the activity of endogenous luliberin, which stimulates the release of gonadotropins (luteinizing and follicle - stimulating hormones) from the anterior pituitary into blood, and the maximum concentration of surfagon is recorded 2-3 hours after administration.

An increased level of gonadotropins in blood is maintained for up to 4-5 hours after administration. The biological activity of BAG-Surfagon is 50 times higher than that of endogenous luliberin, which allows the use of this veterinary drug in microdoses and short courses. BAG-Surfagon is destroyed by enzymes more slowly than endogenous luliberin. This ensures its higher biological activity towards the pituitary gonadotropic function.

Dosage:

Cattle:

• For early induction of estrous cycle:

Method 1. Single dose of 50 mcg is administered on the 5-15th day after calving.

Method 2. Single dose of 50 mcg of BAG-Surfagon is administered on the 8-10th day after calving, then single dose of 250 mcg of estrofan is administered on the 18-20th day after calving (regardless of the condition of the uterus) and single dose of 15-25 mcg of BAG-Surfagon is administered on the 36th day after calving.

• For treatment of ovarian hypofunction – double administration: dose of 50 mcg is administered on the 8-12th day of estrous cycle and dose of 10-25 mcg is administered 10 days after the first administration.
• For treatment of ovarian follicular cysts – 25 mcg is administered 3 times with 24 hours intervals. Single dose of 250 mcg of estrofan or 100-200 mcg of clathraprostin is administered on the 11th day after the first administration of BAG-Surfagon, 2 times, at 10-12 hours intervals.
• For prevention of perinatal mortality – single dose of 50 mcg is administered on the 8-12th day after insemination.
• For improvement of fertility of cows and heifers – double dose of 250 mcg of estrofan or 100-200 mcg of clathraprostin is administered on the 10-14th day of estrous cycle, at 10-12 hours intervals. Dose of 50 mcg of BAG-Surfagon is administered at the beginning of estrous or 70 hours after the first administration of estrofan or clathraprostin, then animals are inseminated. Single dose of 50 mcg of BAG-Surfagon is administered on the 8-12th day after insemination.
• For induction of superovulation in donor cows – single dose of 25 mcg is administered in the first 2-4 hours of induced estrous, or 42-46 hours after the administration of prostaglandins in donor cows.

Pigs (sows):

• For induction of estrous and improvement of fertility – Single dose of 1000 IU of mare serum is administered 24-48 hours after the weaning piglets, then single dose of 50 mcg of BAG-Surfagon is administered 56 hours after the administration of mare serum.
• To stimulate the development of the reproductive organs of gilts 60 and 30 days before the scheduled insemination, the drug is administered intramuscularly in a dose of 2 ml (which corresponds to 10 μg of surfagon) per animal.

Sheep (ewes):

• For improvement of fertility – Single dose of 12-15 mcg is administered.

Precautions and adverse reactions:

In recommended doses the veterinary drug doesn’t cause side effects and complications.

Do not use the drug during pregnancy.

The peculiarities of the drug's action during the first use and cancellation were not revealed.

Symptoms of an overdose were not revealed when using the drug.

Avoid missing the next dose of the drug, as it may lead to the reduced therapeutic effect. If administration of the veterinary drug is missed, resume it in the same dosage and according to the same treatment scheme.

Do not mix the drug in one syringe with other veterinary drugs. 

Withdrawal period:

Milk and meat for human consumption during the period of treatment and after it may be taken without limits.

Storage conditions:

Store in a dry, dark place at a temperature of +2C to +10C. Keep out of reach of children.

Shelf-life:

Shelf-life of the veterinary drug under appropriate storage conditions is 2 years from the date of manufacture. Shelf-life after first opening: 28 days.