BAG-Gonadorelin

Therapeutic indications:

The drug is used to regulate reproductive function in cattle and dogs.

Pharmacotherapeutic group:

Estrogens, gestagens; their homologues and antagonists.

Dosage form description

Solution for intramuscular administration. In appearance, the drug is a clear, colorless solution. 10 ml colorless glass vials.

Composition of the veterinary drug:

1 ml of the drug contains 100 mcg of gonadorelin (as gonadorelin acetate) as the active substance.

Pharmacological activity:

Gonadorelin, the active substance of the drug, is a synthetic peptide, an analogue of natural gonadoliberin. The pharmacological action of parenteral administration of the drug is completely identical to the action of natural gonadoliberin, namely gonadorelin induces the formation and release of follicle-stimulating and luteinizing hormones from the adenohypophysis, growth and maturation of follicles, synthesis and secretion of estrogens, stimulates ovulation, and controls the function of the ovarian corpus luteum.

Upon parenteral administration, the half-life of gonadorelin is 8–10 minutes. The drug is rapidly metabolized in the animal organism, and up to 90% is excreted in the urine. Regarding its degree of impact on the organism, the drug does not exhibit sensitizing, embryotoxic, or teratogenic effects.

Dosage:

The drug is administered intramuscularly in the following doses.

In cattle (cows, heifers): 

• for the induction of ovulation and increasing fertilization rate – 2.5–5 ml of the drug (corresponding to 250–500 mcg of gonadorelin) immediately before artificial insemination (30 minutes prior) or 2 hours prior, once;
• for follicle persistence and delayed ovulation (metrorrhagia 1–2 days after the end of estrus) in the subsequent estrus cycle – twice, 2.5 ml of the drug (corresponding to 250 mcg of gonadorelin) 30–60 minutes before artificial insemination and 2 hours after;
• to improve reproduction rates – on days 11–14 of the estrous cycle, 1–2.5 ml of the drug (corresponding to 100–250 mcg of gonadorelin), having a positive effect on follicle maturation, subsequent ovulation, and accordingly preventing the formation of ovarian cysts;
• for the normalization of the estrous cycle rhythm in the postpartum period – 1–2.5 ml of the drug (corresponding to 100–250 mcg of gonadorelin) on days 20–30 after calving, once;
• in the treatment of animals with follicular cysts – 5 ml of the drug (corresponding to 500 mcg of gonadorelin) once.

In female dogs:

• for the stimulation of ovulation – 0.5–1 ml of the drug (corresponding to 50–100 mcg of gonadorelin) once.

In male dogs:

• for cryptorchidism – 0.5–1 ml of the drug (corresponding to 50–100 mcg of gonadorelin) 3–4 times at intervals of 4–5 days.

Contraindications:

Contraindicated in animals with hypersensitivity to the components of the drug.

Overdose:

Symptoms of overdose during drug administration in animals have not been identified.

Pregnancy and lactation:

It is prohibited to use the drug during pregnancy after a two-week term.

Special indications:

No specific effects of the drug upon initial use or withdrawal have been identified. Skipping a dose should be avoided, as this may lead to a decrease in therapeutic efficacy. If a dose is missed, administration should be resumed at the same dose and according to the same schedule. It is prohibited to use the drug in debilitated animals, those below average body condition, as well as those that have not reached sexual maturity.

Side effects and individual intolerance:

Adverse events and complications are generally not observed when using the drug in accordance with these instructions.

Withdrawal period:

Products obtained from animals treated with the drug may be used for food without restriction.

Shelf-life:

2 years from the date of manufacture. The drug must not be used after the expiration date.

Storage conditions:

In a dry place protected from light at temperatures from 2 °C to 25 °C. The drug should be stored in a place out of the reach of children. After initial opening of the vial – 28 days under appropriate storage conditions.