Oxytocin 10

Therapeutic indications:

The drug is used for the treatment of female animals in following cases:

• uterine inertia (contractions and exertions),
• uterine bleeding,
• retained placenta,
• atony,
• hypotension,
• postpartum endometritis and subinvolution of uterus,
• mastitis,
• agalactia.

Composition of the veterinary drug:

1 ml of the preparation contains:

• 10 IU of oxytocin as an active substance.

Pharmacological activity:

OXYTOCIN 10 is a hormonal drug with oxytocin as the active substance of the drug. Oxytocin is is a synthetic analogue of a polypeptide hormone produced by the posterior lobe of the pituitary gland in mammals. It increases the permeability of myofibrils for sodium ions. Also oxytocin increases the tonus, enhances the contraction of the uterus smooth muscles and myoepithelial cells surrounding the mammary gland alveoli. Oxytocin has weak vasopressin-like and antidiuretic properties.

Oxytocin has a relaxing action on smooth vascular muscles, that leads to temporary arterial hypotension and reflex tachycardia.

The effect of oxytocin on the uterus smooth muscles manifests itself in 1-3 minutes after subcutaneous and intramuscular administration. Oxytocin has a short-term action that lasts from 20 to 30 minutes.

The drug is inactivated in the liver and kidneys. A small amount of oxytocin is excreted with urine. The half-life of oxitocine in the animal body is 5-7 minutes.

Dosage:

The drug is injected subcutaneously, intramuscularly or may be administered as an intravenous infusion in the following doses (Table 1):

Table 1.

To stimulate the placenta expulsion in cows use the drug on the first day after calving.

During the postpartum period, the drug is used to accelerate the involution of uterus.

The drug is used in female dogs after manual reduction of uterus prolapse in order to accelerate its involution.

When the drug is used to stimulate parturition in cows and female horses, the dosage may be increased by 1.5 times.

Precautions and adverse reactions:

When used in accordance with this instruction, side effects and complications are generally not observed.

Do not use in animals with hypersensitivity to the components of the drug, in the case of assisted parturition with a large fetus and a contracted pelvis, deformities, fetus malposition, twisting of the uterus, during pregnancy and a closed cervix, as well as multiple pregnancies and uterine wall scars.

After the first administration and cancellation, no peculiarities of the drug use are revealed.

The effects of the drug overdose depend on the uterus condition and the fetus (or fetuses) position. 

The development of hypertensive or tetanic contractions may be resulted in secondary weak contractions and heaves during parturition, rupture of the uterus, fetal hypoxia and fetal death. In this case, the drug should be cancelled; symptomatic treatment should be prescribed (fluid injection decrease, forced diuresis, administration of hypertonic sodium chloride solution and improvement of electrolyte balance).

Do not use the drug simultaneously with fibrinolysin, norepinephrine and meterazine.

Withdrawal period:

No withdrawal period for milk and meat. Meat and milk may be used for human consumption without any restrictions after the last drug administration.

Storage conditions:

Store in a dark place at a temperature between + 2 ° C to + 8 ° C.

The drug should be kept out of the reach of children.

Shelf-life:

Shelf-life of the veterinary drug is 24 months from the date of manufacture. Shelf-life after first opening of the bottle (vial) is 28 days under appropriate storage conditions.