Uterobag

Therapeutic indications:

The drug is used in cows and sows:

• to increase reproductive function,
• to prevent  postpartum complications;
• to treat retained placenta, atony and uterine hypotension,
• to treat postpartum endometritis and uterine subinvolution,
• to treat metritis-mastitis-agalactia syndrome in sows;
• to increase fertilisation rate,
• in the case of embryo extraction in donor cows.

Composition of the veterinary drug:

1 ml of the drug contains:

• 5 mg of propranolol hydrochloride as an active substance.

Pharmacological activity:

UTEROBAG is a non-selective beta-adrenergic blocking agent.

Propranolol, which is the active substance of the drug, inhibits beta-adrenoreceptors of myometrium, that leads to the endogenous oxytocin production and smooth muscles of the uterus and mammary gland contractions. Propranolol is a catecholamine antagonist, which has a powerful anti-stress effect.

The drug enhances spontaneous uterine contractions induced by uterotonic drugs. UTEROBAG reduces uterine bleeding during parturition and post-surgical period.

The drug is well absorbed from the injection site and quickly distributed throughout the body. The maximum concentration in the blood is reached 5-10 minutes after the administration of the drug. Propranolol crosses the blood-brain and placental barriers. The drug is metabolized in the liver, some of the metabolites have a weak beta-blocking activity. The half-life of propranolol is 3-5 hours. The time of complete elimination is 12 hours. The drug is excreted from the body mainly with urine and partly with faeces in the form of metabolites.

Dosage:

The drug is administered via intramuscular or intravenous injection.

The drug is administered at a dose of 10 ml per animal, which corresponds to 50 mg of propranolol hydrochloride per animal:

·       to facilitate parturition in cows; for the prevention of postpartum complications – once, on the day of parturition;

·       for the treatment of retained placenta in cows – three times, with an interval of 12 hours;

·       in the case of subinvolution of the uterus and postpartum endometritis in cows – three times, with an interval of 24 hours in combination with other drugs.

The drug is administered at a dose of 5 ml per animal (25 mg of propranolol hydrochloride per animal):

·       for the prevention of metritis-mastitis-agalactia syndrome in sows – once, immediately after parturition;

·       in the case of artificial insemination to increase the breeding efficiency in cows and sows – once, 20-30 minutes before the parturition;

·       in the case of embryo extraction in donor cows – 10-15 minutes before washing out.

Precautions and adverse reactions:

When the drug is used in recommended doses and in accordance with all the instructions, side effects and complications are generally not observed. If allergic reactions occur, the use of the drug is stopped and antihistamine and symptomatic drugs are prescribed to the animal.

Overdose symptoms (reduced heart rate, hypotension, bronchospasm, muscle weakness) may be observed. If side effects are manifested to a greater extent, especially sustained bradycardia, due to an overdose, atropine and beta-adrenoceptor agonist (isoprenaline, orciprenaline and others) should be prescribed according to their instructions for use.

Do not use the drug during pregnancy and in the case of abnormal parturition (fetal size, deformities, developmental anomalies). For lactating animals, the drug is used according to indications, with caution, under the supervision of a veterinarian.

Do not use the drug simultaneously with adrenomimetics (the active substance of which is xylazine), since propranolol prolongs the action of nondepolarizing muscle relaxants. Do not use the drug simultaneously with sedating medications and sleeping drugs, which contains propranolol as an active substance, because in this combination propranolol has depressant effects onto the central nervous system (CNS) in animals.

With intravenous and intramuscular administration of iodine-containing drugs while taking propranolol, the risk of anaphylactic reactions increases.

After the first administration and cancellation, no warnings and precautions for the drug use are revealed.

If administration of the drug is missed, resume it in the same dosage according to the same treatment scheme. Do not give a double dose to offset a missed one.

Withdrawal period:

Animal products may be used for human consumption without any restrictions after the last drug administration.  

Storage conditions:

The drug should be stored in a dark place at a temperature between + 2 °C to + 25 °C.

The drug should be kept out of reach of children.

Shelf-life:

Shelf-life of the veterinary drug is 2 years from the date of manufacture. Shelf-life after the first opening of the bottle is 14 under appropriate storage conditions. Do not use the drug after the expiry date. Unused veterinary drug should be utilized in accordance with the requirements of the law.

Available without prescription.