Carotil

Veterinary drug CAROTIL

A complex preparation that is used for the treatment of uterine diseases in cows

Highly effective in the treatment of endometritis

Broad spectrum of antimicrobial action

Restores uterine contractile function

Promotes regeneration of endometrium

Short withdrawal period for milk

Stress- and pain-free treatment

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Therapeutic indications:

The drug is used for the treatment of inflammatory processes in the uterus; as well as after cesarean section, in the case of assisted parturition and surgical removal of placenta in cows.

Composition of the veterinary drug:

100 ml of the drug contains:

• 1 g of tylosin tartrate

• 0.005 g of carbachol

• 0.04 g of beta-carotene

Pharmacological activity:

The drug has a broad spectrum of antimicrobial activity; facilitates the restoration of contractile function and regeneration of uterine mucosa in cows with endometritis.

Tylosin is the active substance of the drug with bacteriostatic effect. Tylosin acts against most gram-positive and some gram-negative microorganisms, including: Staphylococcus spp., Streptococcus spp., Corynebacterium spp., Clostridium spp., Actinomycеs spp., Pasteurella spp. and etc. Also tylosin is highly effective against Mycoplasma spp., Chlamidia spp. и Ureplasma spp.

The mechanism of action of tylosin is based on the inhibition of protein synthesis in the microbial cell by suppressing the enzyme translocase.

Beta-carotene has antioxidant characteristics through the fixation of active oxygen; beta-carotene inhibits free radical chain reactions and protects macromolecules and cell biomembranes from damage, thus ensuring the increase of the body's resistance to various pathogenic influences. Beta-carotene activates metabolism, promotes endometrial regeneration, and prevents placenta retention.

Carbachol increases tonus and enhances muscles contraction of the uterus.

The active substances of the drug in small quantities penetrate from the uterine cavity into organs, tissues and body fluids. These active substances are excreted from the body of animals mainly with exudate during uterus contractions.

Dosage:

For the treatment of postpartum endometritis, the drug is administered in uterus at a dose of 50-60 ml of the drug per animal, using Janet's syringe, with an interval of 48 hours, until the affected cows completely recover.

For the treatment of chronic endometritis, the drug is administered in uterus at a dose of 40-50 ml of the drug per animal, with an interval of 48 hours within 6-8 days.

For uterine lavage, the drug is administered in uterus at a dose of 15-20 ml of the drug per animal, 12-24 hours after artificial insemination.

After cesarean section, assisted parturition or surgical removal of placenta in cows, the drug is given as a single dose of 50-60 ml of the drug per animal.

Precautions and adverse reactions:

Before using the drug, the veterinary drug should be heat to + 36-38 ° C and shaken thoroughly.

If symptoms of an allergic reaction occur (dermatitis, itching, edema), the drug should be cancelled; desensitizing therapy, antihistamines, calcium, a glucose solution should be prescribed.

Do not use in animals with hypersensitivity to the components of the drug, as well as in animals with cardiac diseases, severe liver and kidney dysfunctions.

After the first administration and cancellation, no peculiarities of the drug use are revealed.

If administration of the veterinary drug is missed, resume it in the same dosage according to the same treatment scheme. It is not recommended to take a double dose to offset a missed one.

Do not use this drug simultaneously with antibiotics of the penicillin and cephalosporin groups.

Withdrawal period:

Milk obtained during the treatment period and within 48 hours after the last drug administration is allowed for animal feeding after thermal treatment.

Animals must not be slaughtered for human consumption before 72 hours after the last drug administration. Meat of animals forcibly slaughtered before the specified period expires may be used for feeding carnivores.

Storage conditions:

Store in a dark place at a temperature between + 2 ° C to + 25 ° C.

The drug should be kept out of reach of children.

Shelf-life:

Shelf-life of the veterinary drug is 12 months from the date of manufacture. Shelf-life after the first opening of the bottle (vial) is 14 days under appropriate storage conditions.