Uterofur

Therapeutic indications:

The drug is used for the treatment of chronic endometritis including subclinical endometritis.

Composition of the veterinary drug:

19 g of the drug (one syringe) contains:

• 500 mg of ceftiofur hydrochloride as an active substance.

Pharmacological activity:

UTEROFUR is an antibacterial drug. It contains ceftiofur as an active substance, a third generation semi-synthetic cephalosporin. Ceftiofur has a broad spectrum of action against gram-positive and gram-negative bacteria such as Treuperella (Arcanobacterium) pyogenes, Streptococcus spp., Staphylococcus spp., Escherichia coli, Fusobacterium necrophorum, Bacteroides spp., Klebsiella spp., Pasteurella spp., Proteus spp., etc.

Сeftiofur inactivates penicillin-binding proteins involved in the synthesis of the peptidoglycan, main biopolymer of bacterial cell wall. It hinders the process of assembly of pentidoglycan chains, that leads to the cell wall weakening and further bacteria lysis.

In the uterine cavity ceftiofur is rapidly metabolized to desfuroylceftiofur, which has bactericidal activity equivalent to ceftiofur. This active metabolite reversibly binds to proteins and is accumulated in the infection site. Decreased activity of ceftiofur in the presence of necrotic tissues is not observed. After intrauterine administration less than 1% of the drug is absorbed; the systemic effect is almost absent.

Dosage:

The drug is administered via intrauterine injection at a single dose of 19 g (one syringe).

Before the intrauterine administration of the drug, the external genital organs and the root of the tail are treated with an antiseptic. If necessary, the inflammatory exudate should be removed from the uterine cavity. Connect the syringe to the catheter. Use a disposable glove to rectally fix the cervix, then carefully insert the catheter through the cervix into the uterine cavity and squeeze out the syringe content.

If necessary, the injection is repeated in 24 hours in the same dose.

Precautions and adverse reactions:

When the drug is used in recommended doses and in accordance with all the instructions, side effects and complications are generally not observed. If symptoms of an allergic reaction occur, the drug should be cancelled and antihistamines and calcium should be prescribed.

Do not use in animals with hypersensitivity to the components of the drug, as well as to cephalosporins and other beta-lactam antibiotics.

No overdose symptoms when using the drug have been observed.

Do not use the drug simultaneously with tetracycline, macrolide and lincosamide antibiotics.

Withdrawal period:

Animals must not be slaughtered for human consumption within 48 hours after the last drug administration. Meat of animals forcibly slaughtered earlier than the specified period expires may be used to feed carnivores.

Milk may be used for human consumption without any restrictions after the drug administration.

Storage conditions:

The drug should be stored in a dark place at a temperature between 2 °C to 25 °C. 

Shelf-life:

Shelf-life of the veterinary drug is 2 years from the date of manufacture.