Gonadorelin 50

Therapeutic indications:

Gonadorelin 50 is indicated for the control of reproduction cycle in cattle and pigs.

• cattle - for the induction of ovulation of follicles with a deficiency of luteinizing hormone, synchronization of ovulation, stimulation of ovarian function in the postpartum period, as well as for follicular ovarian cysts treatment;
• pigs - to synchronize ovulation, increase fertility.

Composition of the veterinary drug:

1 ml Gonadorelin 50 solution for injection contains:

50 mkg of gonadorelin acetateas an active substance

Pharmacological activity:

Gonadorelin, the active ingredient of the drug, is a synthetic peptide, an analogue of natural GnRH. The action of the drug when administered parenterally in terms of pharmacological action is completely identical to the action of natural gonadoliberin, that is, gonadorelin induces the formation and release of follicle-stimulating and luteinizing hormones from the adenohypophysis, the growth and maturation of follicles, the synthesis and secretion of estrogens, stimulates ovulation and controls the function of the corpus luteum of the ovaries.

After a single intramuscular injection of the drug, gonadorelin is rapidly absorbed from the injection site and reaches its maximum concentration in the blood serum within 15 minutes. The bioavailability of gonadorelin is about 89%. The highest concentration of the hormone was found in the liver, kidneys and lungs. Within 8–24 hours, gonadorelin binds to blood proteins up to 73%. Gonadorelin is rapidly excreted in milk, urine and feces as inactive metabolites.

The veterinary drug does not have sensitizing, embryotoxic and teratogenic effects.

Dosage:

The drug is administered intramuscularly and subcutaneously in the following doses.

• Cattle (cows, heifers) intramuscularly (in the neck or inner thigh area):
  - for the induction of ovulation after estrus synchronization - 1-2 ml of the drug per animal;
  - with persistence of the follicle and delayed ovulation - 2 ml of the drug per animal 2 hours before artificial insemination and 2 hours after it;
  - to stimulate ovarian function in the postpartum period - 1 ml of the drug per animal on the 12th day after calving;
  - for the treatment of follicular ovarian cysts - 2-3 ml of the drug for administration to one animal once.
• Pigs to synchronize ovulation and increase fertility intramuscularly or subcutaneously in doses:
  - sows - 0.5-1 ml of the drug per animal;
  - replacement pigs - 1-1.5 ml of the drug per animal.

Precautions and adverse reactions:

Do not use in animals which are known to be hypersensitive to drug's components. Do not use in combination with other hormonal drugs. Combined use with chorionic gonadotropin may lead to ovarian hyperstimulation. Combination therapy with follicle-stimulating hormone (FSH) may lead to a synergistic effect.

When used according to the instructions, the veterinary drug doesn’t cause side effects and complications.

Do not use in animals which are weakened and are below medium weight, as well as which have not reached puberty, during pregnancy in a two-week period.

No overdose symptoms have been observed.

After the first administration as well as the cancellation of the drug, no peculiarities have been revealed.

Avoid missing the next dose of the drug, as it may lead to the reduced therapeutic effect. If administration of the veterinary drug is missed, resume it in the same dosage and according to the same treatment scheme.

Withdrawal period:

No withdrawal period for milk and meat.

Storage conditions:

Store in a dry, dark place at a temperature of 2º to 25º C. Keep out of reach of children.

Shelf-life:

Shelf-life of the veterinary drug under appropriate storage conditions is 2 years from the date of manufacture. Shelf-life after first opening: 28 days.