Tilmicoforce-O

Therapeutic indications:

The drug is prescribed to calves, pigs and poultry  (broilers, breeding poultry, poultry of the parent flock, repair young chickens) for the treatment of respiratory diseases (mycoplasmosis, pasteurellosis, ornithobacteriosis, bordetellosis, dysentery, streptococcosis) and other infections caused by microorganisms sensitive to tilmicosin.

Composition of the veterinary drug:

1 ml of the dug contains:

• 250 mg tilmicosin (in a form of tilmicosin phosphate) as an active substance.

Pharmacological activity:

The drug belongs to antibacterial agents of the macrolide group. 

Tilmicosin, the active ingredient of the drug, is active mainly against gram-positive and some gram-negative microorganisms (Actinobacillus pleuropneumoniae, Mannheimia haemolytica, Pasteurella multocida, Staphylococcus spp., Streptococcus spp., Ornithobacterium rhinotracheale, Clostridium spp., Corynebacterium spp., Brachyspira spp., Bordetella spp., Spirochaeta spp., etc.), as well as Mycoplasma spp. and Chlamydia spp.

The mechanism of the bacteriostatic action of tilmicosin is based on suppression of protein biosynthesis in a bacterial cell at the ribosomal level.

After oral administration of the drug, tilmicosin is quickly absorbed in the gastrointestinal tract and penetrates into most organs and tissues of the body, reaching a maximum level in the blood serum in 1.5–3 hours. The therapeutic concentrations of the antibiotic remain in the body for 24 hours. Tilmicosin is excreted from the body mainly unchanged, mainly with feces and partly with urine.

Dosage:

The drug is administered to animals and poultry orally, individually or in groups in the following doses: 

• poultry - with drinking water in a daily dose of 300 ml of the drug per 1000 l of water (which corresponds to 75 mg of tilmicosin per 1 l) for 3 days using flock treatment;
• pigs - with water for drinking in a daily dose of 15-20 mg of tilmicosin per 1 kg of animal body weight (which corresponds to 800 ml of the drug per 1000 liters of water) for 5 days using herd treatment; 
• for calves - individually with drinking water, milk or milk replacer twice a day in a dose of 0.5 ml of the drug per 10 kg of animal body weight (12.5 mg of tilmicosin per 1 kg of animal body weight) for 3-5 days.

An aqueous solution of the drug is prepared on a daily basis, in a volume that equals the daily consumption volume. Milk-based formulation and milk replacer solutions are stable for 6 hours. 

The daily dose of the drug may be given by the pulse dosing method for 4-6 hours. During the treatment period, animals and poultry should receive only a drug-containing solution, which is not mandatory when using the pulse dosing procedure.

Precautions and adverse reactions:

When used in accordance with the instruction, side effects are generally not observed. In animals and poultry with increased individual sensitivity to the drug components an allergic reaction may occur. in this case, the drug is cancelled; antihistamines and other symptomatic treatment are prescribed.

Do not use the drug in animals and poultry with increased individual sensitivity to the components of the drug, as well as in animals and poultry with severe liver and kidney dysfunctions. It is not recommended to use the drug in ruminants with developed cicatricial digestion.

In case of overdose of the veterinary drug, decreased appetite, decreased water intake and weight loss may be observed. In these cases, the drug is cancelled; measures to accelerate drug clearance from the body is undertaken.

The drug should not be used simultaneously and within 7 days before and after the use of ionophore coccidiostatics, antibiotics of the aminoglycoside group, due to the possible occurrence of side effects and complications (allergy, dysbiosis, anorexia). In order to prevent a decrease in antibacterial activity, the drug should not be used simultaneously with drugs and feed additives containing bentonite.

After the first administration and cancellation of the drug, no peculiarities for the drug use are revealed.

Avoid missing the next dose of the drug, as it may lead to the reduced therapeutic effect. If administration of the veterinary drug is missed, resume it in the same dosage and according to the same treatment scheme as soon as possible. Do not increase the dose to compensate the missing one.

The drug can be used in animals during pregnancy and lactation.

Do not use in poultry, which eggs are used for human consumption, as well as in repair young chickens less than 2 weeks before the start of egg laying.

Withdrawal period:

Pigs and poultry must not be slaughtered for human consumption before 16 days, calves – before 42 days after the last drug administration. Meat of animals and poultry forcibly slaughtered earlier than the specified period expires may be used for feeding carnivores.

Storage conditions:

The drug should be stored in a dark place at a temperature between + 2 °C to + 25 °C. The drug should be kept out of reach of children.

Shelf-life:

Shelf-life of the veterinary drug is 2 years from the date of manufacture. Shelf-life after the first opening of the bottle is 28 days under appropriate storage conditions. The prepared working solution should be used within a day. The prepared solution based on milk and milk replacer is usable within 6 hours. Do not use the drug after the expiry date.