Tilmikofors

Therapeutic indications:

The drug is used in cattle for the treatment of necrobacillosis, bovine respiratory diseases (BRD) caused by tilmicosin-sensitive microorganisms.

Composition of the veterinary drug:

1 ml of the drug contains:

• 300 mg of tilmicosin phosphate as an active substance.

Pharmacological activity:

TILMIKOFORS is an antibacterial drug.

The active substance of the drug is tilmicosin. It has a broad spectrum of action against many gram-positive Streptococcus spp., Staphylococcus spp., Clostridium spp., Corynebacterium spp., some gram-negative microorganisms Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, Mycoplasma spp., Dichelobacter nodosus, Fusobacterium necrophorum, as well as against Actinomyces spp. and obligate intracellular microorganisms of the genus Chlamydia.

Tilmicosin binds to the 50S ribosomal subunit and that leads to the protein synthesis suppression in the bacterial cell.

Being administered via one subcutaneous injection, tilmicosin reaches its maximum concentration in the blood in one hour. Tilmicosin accumulates in the lung tissue, penetrating into the alveolar macrophages. A high therapeutic concentration of tilmicosin is maintained for three days. Tilmicosin is excreted from the body mainly with faeces, partly with urine.

Dosage:

The drug is administered to cattle via single subcutaneous injection:

·       for the treatment of pneumonia: at a dose of 10 mg of tilmicosin per 1 kg of body weight, which corresponds to 1 ml of the preparation per 30 kg of body weight;

·       for the treatment of necrobacillosis: at a dose of 5 mg of tilmicosin per 1 kg of body weight, which corresponds to 0.5 ml of the drug per 30 kg of body weight.

Do not inject more than 20 ml of the drug in one injection site вue to the possible pain reaction.

Сontraindications:

Do not use in animals with hypersensitivity to tilmicosin and other constituents of the drug.

Overdose:

In case of an overdose, side effects such as loss of appetite, low water consumption and weight loss may be observed. In rare cases, in case of an overdose and / or unintentional intramuscular administration of the drug, shortness of breath may be observed. There are no specific means of detoxification, general measures aimed at clearing the drug from the body are used.

Pregnancy and lactation:

Do not use this drug in animals during lactation period.

Special notes:

The peculiarities of the action during the first use of the drug were not revealed.

Side effects and individual intolerance:

When the drug is used in recommended doses and in accordance with all the instructions, side effects and complications are generally not observed. Sometimes swelling may be observed that naturally disappears within 5-8 days.

Animals with increased individual sensitivity to the drug's components may experience persistent allergic reactions (erythema, itching, swelling). In this case, if necessary, antihistamines and other symptomatic treatment should be prescribed.

Interaction with other veterinary drugs:

Do not use this drug simultaneously with drugs of the penicillin and cephalosporin groups.  The drug should not be used simultaneously with adrenaline and beta-adrenoreceptor blocking agents (propranolol and others).

Withdrawal period:

If the drug is used in cows during the dry period, milk may be used for human consumption 36 days after calving. Before this period expires, heat-treated milk may be used for feeding carnivores.

Cattle must not be slaughtered for human consumption before 60 days after the last treatment. Meat of animals forcibly slaughtered earlier than the specified period expires may be used for feeding carnivores.

Form of production:

Dark glass bottles of 100 ml.

Storage conditions:

The drug should be stored in a dark place at a temperature between + 2 °C to + 25 °C.

The drug should be kept out of reach of children.

Shelf-life:

Shelf-life of the veterinary drug is 2 years from the date of manufacture. Shelf-life after the first opening of the bottle is 28 days under appropriate storage conditions.