Veterinary drug ENMITRIL-O

For the treatment of infectious diseases in calves, lambs, pigs and poultry

  • Broad-spectrum antibacterial drug

  • Contains antibiotic enrofloxacin as an active substance

  • Quickly penetrates in organs and tissues after administration

  • Active in organism for 24 hours

  • Administered orally

Therapeutic indications:

ENMITRIL-O is used in calves, lambs, pigs and poultry (broilers, breeding poultry, replacement chickens, turkeys) for the treatment of bronchopneumonia, colibacillosis, salmonellosis, streptococcosis, necrotizing enteritis, campylobacter hepatitis, hemophilia, mycoplasmosis and other diseases, wich causative agents are sensitive to enrofloxacin.

Composition of the veterinary drug:

1 ml of the drug contains as active ingredients:

  • 100 mg of enrofloxacin

Pharmacological activity:

The drug belongs to the antibacterial agents of the fluoroquinolone group.

Enrofloxacin, the active ingredient of the drug, has a broad spectrum of antibacterial action. It is highly effective against gram-positive and gram-negative microorganisms, including Escherichia coli, Salmonella spp., Pasteurella multocida, Mannheimia haemolytica, Staphylococcus aureus, Staphylococcus hyicus, Streptococcus spp., Klebsiella spp., Pseudomonas aeruginosa, Bordetella bronchiseptica, Campylobacter spp., Trueperella (Corynebacterium) pyogenes, Proteus spp., Actinobacillus spp., Listeria monocytogenes, Haemophilus spp., Clostridium perfringens, а также Mycoplasma spp.

Enrofloxacin inhibits the activity of the enzyme gyrase, which affects the DNA replication in the bacterial cell.

After oral administration, enrofloxacin is well absorbed from the gastrointestinal tract and is rapidly distributed throughout the body. The antibiotic reaches its maximum concentration in the blood after 1–2 hours. The therapeutic concentration of enrofloxacin in the blood is maintained for 24 hours after drug administration. In the animal organism enrofloxacin is partially metabolized to form an active metabolite ciprofloxacin, which also reveals antibacterial activity. Fluoroquinolones is excreted mainly with urine and bile.


The drug is administered orally with drinking water in following daily doses:

  • 0.5-1 ml of the drug per 1 liter of drinking water to poultry or 0.1 ml of the drug per 1 kg of body weight, which corresponds to 10 mg of enrofloxacin per 1 kg of body weight. The treatment period is 3 days, and with salmonellosis - 5 days;
  • 2.5–5 mg of enrofloxacin per 1 kg of body weight to calves, lambs and pigs individually or by group method, which corresponds to 0.25–0.5 ml of the drug per 10 kg of body weight, for 3-5 days;

In case of salmonellosis, a two-fold therapeutic dose of the drug is recommended.

A solution of the drug should be prepared every day based on the needs of animals and poultry in water. Drug administration via pulse or continuous dose is also possible. Animals and poultry should receive only water containing the drug during the treatment period (except pulsed medication).

Precautions and adverse reactions:

When the drug is used in accordance with all these instructions, side effects are generally not observed. In animals and poultry with increased individual sensitivity to the components of the drug, allergic reactions may occur. In this case, stop using the drug. If necessary, antihistamines are administred, symptomatic treatment is carried out.

Do not use the drug in animals and poultry with increased individual sensitivity to the components of the drug.

In case of an overdose of the drug, there may be a decrease in appetite, depression, diarrhea, vomiting. In this case, the use of the drug is canceled and symptomatic treatment is prescribed.

Do not use the drug simultaneously with tetracyclines, macrolides, lincosamides.

Do not use the drug in pregnant, lactating females and newborn animals due to disorder of cartilage tissue formation.

After the first administration and cancellation, no peculiarities of the drug use are revealed.

Avoid missing the next administration of the drug to animals (poultry), as this may lead to a decrease in therapeutic efficacy. If administration of the veterinary drug is missed, resume it in the same dosage according to the same treatment scheme. It is not recommended to use a higher doses to offset a missed one.

Do not use the drug in poultry eggs of which are used for human consumption. Do not use the drug in replacement chickens less than 2 weeks before the start of egg laying.

Withdrawal period:

Animals should not be slaughtered for human consumption within 14 days, poultry - 5 days after the last treatment. Meat of animals forcibly slaughtered earlier than the specified period expires may be used for feeding carnivores.

Storage conditions:

Store in a dark place at a temperature between +2°C to +25°C. The drug should be kept out of the reach of children.


Shelf-life of the veterinary drug is 2 years from the date of manufacture. Shelf-life after the first opening of the bottle is 14 days under appropriate storage conditions. The prepared working solution should be used within a day. Do not use the drug after the expiry date. Unused veterinary drug should be utilized in accordance with the requirements of the law. Available without prescription.

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