Veterinary drug COLISTIN-O

The drug is used for the treatment of gastrointestinal infections in calves, lambs, pigs and poultry

  • Bactericidal activity against gram-negative bacteria

  • Stable in the gastrointestinal tract

  • Poorly absorbed into the blood

  • Oral use

  • No withdrawal period for eggs and chicken meat

Therapeutic indications:

The drug is used for the treatment of escherichiosis (colibacteriosis), salmonellosis, pasteurellosis, pseudomonosis and other infectious diseases of the gastrointestinal tract in calves, lambs, pigs and poultry (to hens: broiler chickens, breeding poultry, poultry of the parent flock, repair young, laying hens), the pathogens of which are sensitive to colistin.

Composition of the veterinary drug:

1 ml of the drug contains:

•          2 000 000 IU of colistin (equivalent to 83 mg of colistin sulfate)

Pharmacological activity:

Colistin is the active substance of the drug, an antibacterial agent of the polymyxin group.

Colistin has bactericidal activity against gram-negative bacteria such as Escherichia coli, Salmonella spp., Pasteurella spp., Bordetella spp., Klebsiella spp., Pseudomonas aeruginosa and others.

The mechanism of action: colistin inhibits the permeability of the cytoplasmic membrane, that leads to its destruction and further lysis of the bacterial cell.

In the gastrointestinal tract of animals and poultry, colistin is not destroyed by enzymes and almost never gets absorbed into the blood, due to this, high concentration of colistin is reached. Colistin does not accumulate in organs and tissues; it is excreted from the body with faeces mainly unchanged form.


The drug is administered orally with drinking water individually or in groups in the following daily dose:

  • Calves, lambs, pigs – 0.5 ml of the drug per 10 kg of body weight, which corresponds to 100 000 IU of colistin per 1 kg of body weight within 3-5 days;
  • Poultry –  0.0375 ml of the drug per 1 kg of body weight of a bird (equivalent to 37.5 ml of the drug per 1 ton of body weight of a bird), that corresponds to 75 000 IU of colistin per 1 kg of body weight within 3-5 days.

The prepared working solution should be used within a day. The working solution of the drug should be prepared on a daily basis. Animals and poultry should receive only water containing the drug during the treatment period.

Precautions and adverse reactions:

When used in accordance with the instruction, side effects and complications are generally not observed. In animals and poultry with increased individual sensitivity to components of the drug symptoms of an allergic reaction occur. In this case, the drug should be cancelled; antihistamines and other symptomatic treatment should be prescribed.

Do not use in animals and poultry with increased individual sensitivity to the components of the drug. Do not use in adult ruminant animals.

Symptoms of overdose are not revealed.

Do not use this drug simultaneously with ampicillin, cephalosporins and aminoglycoside antibiotics.

After the first administration and cancellation, no peculiarities of the drug use are revealed.

Avoid missing the next dose of the drug, as it may lead to the reduced therapeutic effect. If administration of the veterinary drug is missed, resume it in the same dosage and according to the same treatment scheme as soon as possible. Do not increase the dose to compensate the missing one.

It is allowed to use the drug to pregnant and lactating females if it is prescribed by a veterinarian.

Withdrawal period:

No withdrawal period for poultry meat and eggs.

Animals must not be slaughtered for human consumption before 7 days after the last drug administration. Meat of animals forcibly slaughtered before the specified period expires may be used for feeding carnivores.

Storage conditions:

Store in a dark place at a temperature between + 2 ° C to + 25 ° C.

The drug should be kept out of reach of children.


Shelf-life of the veterinary drug is 2 years from the date of manufacture. Shelf-life after the first opening of the bottle is 28 days under appropriate storage conditions. The prepared working solution should be used within 24 hours.

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