Enrofloxaferon-B

Therapeutic indications:

The drug is used in calves and adult cattle for the treatment and prevention of colibacillosis, salmonellosis, pasteurellosis, pseudomonosis, mycoplasmosis, chlamydiosis, campylobacteriosis, mastitis, endometritis, mixed (bacterial-viral) infections and other diseases caused by enrofloxacin-sensitive microorganisms.

Composition of the veterinary drug:

1 ml of the drug contains:

•          0.05 g of enrofloxacin,

•          at least 10,000 IU/ml of antiviral activity of the bovine recombinant interferon (IBR) protein.

Pharmacological activity:

The active substance of the drug is enrofloxacin, antibiotic of the fluoroquinolone group. Enrofloxacin reveals an antibacterial effect against gram-positive and gram-negative microorganisms, including Escherichia coli, Salmonella spp., Enterobacter spp., Klebsiella spp., Pasteurella spp., Pseudomonas spp., Proteus spp., Brucella spp., Chlamydia spp., Campylobacter spp., Corynebacterium spp., Staphylococcus spp., Streptococcus spp., Actinobacillus spp., Mycoplasma spp., Clostridium spp., Bacteroides spp., Fusobacterium spp.

The mechanism of action: enrofloxacin inhibits the activity of the enzyme DNA-helicase, which leads to the suppression of the malic acid formation in the microorganisms required for DNA synthesis.

Enrofloxacin is quickly and fully absorbed from the injection site. Enrofloxacin is well-distributed in the body. The maximum concentration of the drug in the blood is reached in half an hour or in an hour after the drug administration and maintained for 4-6 hours. The therapeutic concentration of enrofloxacin in the blood is maintained for 24 hours. Enrofloxacin is partially metabolized into ciprofloxacin and excreted from the body mainly with urine and bile.

Recombinant bovine interferon (IBR) has significant immunostimulating activity with species-specific mechanism in cattle. IBR increases the non-specific resistance of the body and contributes to its protection from DNA and RNA-containing viruses.

Dosage:

The drug is injected intramuscularly at a dose of 0.5 - 1.0 ml per 10 kg of body weight every 24 hours for 3 - 5 days. Do not mix with other drugs in the same syringe.

Precautions and adverse reactions:

Do not use in animals with hypersensitivity to fluoroquinolones, as well as during pregnancy. Do not use the drug simultaneously with chloramphenicol, antibiotics of tetracycline and macrolide groups, as well as with non-steroidal anti-inflammatory drugs.

Withdrawal period:

Animals must not be slaughtered for human consumption before 14 days after the last drug administration. It is forbidden to use milk for human consumption during the treatment period and for 4 days after the last drug administration. Meat of animals forcibly slaughtered before the specified period expires may be used for feeding carnivores.

Storage conditions:

Store in a dry, dark place, in the manufacturer's packaging at a temperature between + 4 ° C to + 10 ° C.

Shelf-life:

Shelf-life of the veterinary drug is 18 months from the date of manufacture under appropriate storage conditions.