Tetrafors LA

Veterinary drug TETRAFORS LA

A long-acting broad-spectrum antibacterial drug

  • An antibacterial action against gram-negative and gram-positive microorganisms

  • A long-term action due to magnesium-oxytetracycline combination

  • A therapeutic concentration of the active substances is maintained for 2.5 - 3 days

  • Approved for use in young animals

  • A single or double administration

  • Highly effective for the treatment of mastitis, hoof lesions (footrot) keratoconjunctivitis, mastitis-metritis-agalactia syndrome, respiratory and other infectious diseases

Therapeutic indications:

The drug is used in large and small ruminants, and pigs for the treatment of infectious diseases caused by oxytetracycline-sensitive pathogens, including respiratory diseases of bacterial etiology, pasteurellosis, atrophic rhinitis, enzootic abortion, mastitis, mastitis-metritis-agalactia syndrome, keratoconjunctivitis, hoof lesions (footrot), acute suppurative arthritis, umbilical sepsis, abscess, peritonitis, wound and postpartum infections, anaplasmosis, as well as for the treatment infections concominant to viral diseases.

Composition of the veterinary drug:

1 ml of the drug contains:

  • 200 mg of oxytetracycline as an active substance.

Pharmacological activity:

TETRAFORS LA is an antibacterial drug.

Oxytetracycline is the active substance of the drug. Oxytetracycline is an antibiotic belonging to tetracycline group and has a broad spectrum of antibacterial action.  Oxytetracycline is effective against most gram-negative and gram-positive bacteria, including Escherichia coli, Salmonella spp., Proteus spp., Campylobacter spp., Pseudomonas aeruginosa, Bordetella spp., Pasteurella spp., Haemophilus spp., Actinobacillus spp., Brucella spp., Staphylococcus spp., Streptococcus spp., Listeria monocytogenes, Corynebacterium spp., Erysipelothrix insidiosa, Fusobacterium necrophorum, Clostridium spp. Oxytetracycline is effective against mycoplasma, chlamydia, rickettsia, treponema.

Oxytetracycline suppresses protein synthesis of microorganisms. In a bacterial cell, oxytetracycline binds to the 30S subunit of bacterial ribosomes that results in prevention of the incorporation of new amino acids into the polypetide chain and to the death of microorganisms.

The drug possesses long-term effect due to the complex of oxytetracycline with magnesium.  When administered via intramuscular injection, oxytetracycline is rapidly absorbed from the injection site and reaches maximum concentrations in organs and tissues in 30-50 minutes after the drug administration.  A therapeutic concentration of the antibiotic in the blood serum is maintained for 60-72 hours. Oxytetracycline is excreted from the body mainly with urine and bile, in lactating animals - partly with milk.


The drug is administered to animals via intramuscular injection at a single dose of 1 ml of the drug per 10 kg of body weight (which corresponds to 20 mg of oxytetracycline per 1 kg of body weight).  If necessary, repeat the injection of the drug after 72 hours.

Do not inject more than 20 ml of oxytetracycline per one injection site to cattle. Do not inject more than 5-10 ml per one injection site to small ruminants and pigs.

If the volume of the injected solution per one injection site is more than the specified one, use several injection sites. 

Precautions and adverse reactions:

At the injection site, allergic reactions such as erythema, itching, edema may occur. These symptoms naturally disappear within a few days and do not require treatment. If a severe allergic reaction occurs, intravenous administration of calcium preparations and symptomatic therapy are recommended.

In case of an overdose, side effects such as apathy, food refusal, and a visible inflammatory reaction may be observed. In this case the drug should be cancelled; symptomatic treatment should be prescribed. In animals with increased individual sensitivity to the components of the drug, allergic reactions may occur. In this case, the use of the drug is discontinued, if necessary, antihistamines and other symptomatic treatment are prescribed.

In case of an overdose of the drug, the animal may experience refusal of feed, depression, an inflammatory reaction at the injection site. In this case, the drug is canceled and, if necessary, symptomatic treatment is prescribed.

Do not use the drug in animals with disorders of renal excretory function, mycoses, and in the cases of hypersensitivity to antibiotics of the tetracycline group.

Concomitant use of the drug with corticosteroids and estrogens is contraindicated. It is not recommended to use simultaneously with antibiotics of the penicillin and cephalosporin groups due to a marked decrease in the antibacterial effect of oxytetracycline. Do not mix the drug in one syringe with other medications.

The drug is approved for use in young animals. Oxytetracycline should be used with caution and under medical supervision in pregnant and lactating females.

After the first administration and cancellation, no peculiarities of the drug use are revealed.

Withdrawal period:

Animals must not be slaughtered for human consumption before 30 days after the drug administration. Meat of animals forcibly slaughtered before the specified period expires may be used for feeding carnivores.

Milk of lactating animals must not be used for human consumption and processed within 30 days after the drug administration. Milk obtained from lactating animals during the treatment period is allowed for animal feeding after thermal treatment.

Storage conditions:

Store in a dark place at a temperature between + 2 ° C to + 25 ° C.

The drug should be kept out of reach of children.


Shelf-life of the veterinary drug is 3 years from the date of manufacture. Shelf-life after first opening of the bottle is 28 days under appropriate storage conditions.

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