Inspiromycin 100

Therapeutic indications

The drug is used for the treatment of swine and bovine respiratory diseases (pasteurellosis, hemophilosis, mycoplasmosis), infectious keratoconjunctivitis (IBK) and other diseases of bacterial etiology in pigs and cattle caused by the pathogens, which are sensitive to tulathromycin.

Composition of the veterinary drug

1 ml of the drug contains

•          100 mg of tulathromycin

Pharmacological activity

The active substance of the veterinary drug is macrolide antibiotic tulathromycin.

Tulathromycin has bactericidal activity against gram-positive and gram-negative bacteria, including Mannheimia haemolytica, Pasteurella spp., Haemophilus somnus, Haemophilus parasuis, Mycoplasma bovis, Actinobacillus pleuropneumoniae, Mycoplasma hyopneumoniae, Moraxella bovis, Neisseria spp.

The mechanism of action of the drug is based on the suppression of protein synthesis at the ribosomal level. 

Tulathromycin is rapidly absorbed from the injection site, reaching a peak concentration in plasma in 30 minutes after injection. The drug is slowly excreted from the organism. The drug accumulates in neutrophils and alveolar macrophages, that leads to an increased concentration of tulathromycin in lung tissues. The elimination half-life of tulathromycin is about 90 hours.  The drug is eliminated from the organism by kidneys in unchanged form.

Dosage

The drug is given to pigs via intramuscular injection in the neck as a single dose of 1 ml of the drug per 40 kg of body weight, which corresponds to 2.5 mg of tulathromycin per 1 kg of body weight.  When given to pigs which body weight exceeds 80 kg, do not inject more than 2 ml per injection site.

The drug is given to cattle subcutaneously as a single dose of 1 ml of the drug per 40 kg of body weight, which corresponds to 2.5 mg tulathromycin per 1 kg of body weight. When given to cattle, which body weight exceeds 300 kg, do not inject more than 7.5 ml per injection site.

Precautions and adverse reactions

When used in accordance with the instruction, side effects and complications are generally not observed.

In some animals, a local reaction in the form of edema may occur at the injection site, which disappear spontaneously. In animals with increased individual sensitivity to the components of the drug, allergic reactions may occur. In this case, if necessary, antihistamines are prescribed, symptomatic treatment is carried out.

Do not use in animals with hypersensitivity to the components of the drug.

An overdose of the drug in animals may cause anxiety, loss of appetite. There are no specific antidotes. These symptoms disappear spontaneously without use of symptomatic agents.

Do not use the drug simultaneously with other macrolides or lincosamides. Do not mix the drug with other veterinary drugs in one syringe.

After the first administration and cancellation, no peculiarities have been revealed.

Withdrawal period

Cattle must not be slaughtered for human consumption before 49 days, pigs – before 33 days after the last drug administration.

Meat of animals forcibly slaughtered before the specified period expires may be used for feeding carnivores.

The drug is not allowed for cows producing milk for human consumption.

Do not use the drug in pregnant cows and heifers which are intended to produce milk for human consumption, within 2 months before the expected parturition.

Storage conditions

Store in a dark place at a temperature between 2 °C to 25 °C.

Shelf-life

Shelf-life of the veterinary drug is 3 years from the date of manufacture. Shelf-life after the first opening of the bottle is 28 days under appropriate storage conditions.