Inspiromycin 25

Therapeutic indications:

The drug is used for the treatment of swine respiratory diseases (pasteurellosis, bordetellosis, mycoplasmosis) and other diseases of bacterial etiology in pigs caused by the pathogens, which are sensitive to tulathromycin.

Composition of the veterinary drug:

1 ml of the drug contains:

•          25 mg of tulathromycin.

Pharmacological activity:

The active substance of the veterinary drug is macrolide antibiotic tulathromycin.

Tulathromycin has bactericidal activity against gram-positive and gram-negative bacteria, including Mannheimia haemolytica, Pasteurella spp., Haemophilus somnus, Haemophilus parasuis, Mycoplasma bovis, Actinobacillus pleuropneumoniae, Mycoplasma hyopneumoniae, Bordetella bronchiseptica.

The mechanism of action of the drug is based on suppression of protein synthesis at the ribosomal level. 

Tulathromycin is rapidly absorbed from the injection site, reaching a peak concentration in plasma in 30 minutes after injection. The drug is slowly excreted from the body.

Tulathromycin accumulates in neutrophils and alveolar macrophages, that leads to an increased concentration of the antibiotic in lung tissues.

The elimination half-life of tulathromycin is about 90 hours.

The drug is eliminated from the organism by kidneys in unchanged form.

Dosage:

The drug is given to pigs via intramuscular injection in the neck as a single dose of 1 ml of the drug per 10 kg of body weight, which corresponds to 2.5 mg of tulathromycin per 1 kg of body weight.  When given to pigs which body weight exceeds 40 kg, do not inject more than 4 ml per injection site.

Contraindications:

The drug must not be used in animals with hypersensitivity to the components of the drug.

Overdose:

In case of an overdose of the drug, animals may exhibit restlessness and a decreased appetite. There are no specific antidotes. These symptoms resolve spontaneously without the administration of symptomatic treatments.

Pregnancy and lactation:

No specific effects of the drug on the reproductive function of animals have been identified. The possibility of using the drug during pregnancy and lactation is determined by veterinarian based on an assessment of the benefit-risk ratio.

Special indications:

No specific effects of the drug upon first use have been identified.

Side effects and individual intolerance:

Side effects and complications when using the drug in accordance with these instructions are not typically observed. In some animals, a local reaction in the form of swelling may occur at the injection site, which resolves spontaneously. In animals with increased individual sensitivity to the components of the drug, allergic reactions may occur. In this case, if necessary, antihistamines are prescribed and symptomatic treatment is administered.

Interaction with other veterinary drugs:

It is not recommended to use the drug concomitantly with other macrolides or lincosamides. Do not mix with other medicinal products in the same syringe.

Withdrawal period:

Pigs must not be slaughtered for human consumption before 33 days after the last drug administration.

Meat of animals forcibly slaughtered before the specified period expires may be used for feeding carnivores.

Storage conditions:

Store in a dark place at a temperature between 2 °C to 25 °C.

The drug should be kept out of reach of children.

Shelf-life:

Shelf-life of the veterinary drug is 3 years from the date of manufacture. Shelf-life after the first opening is 28 days.