Respiroflor 300

Therapeutic indications:

RESPIROFLOR 300 is used in:

• pigs for the treatment of actinobacillary pleuropneumonia, infectious atrophic rhinitis, as well as other infectious diseases of bacterial etiology caused by florfenicol-sensitive microorganisms;
• cattle for the treatment of respiratory diseases (BRD), as well as other infectious diseases of bacterial etiology caused by florfenicol-sensitive microorganisms.

Composition of the veterinary drug:

1 ml of the preparation contains:

• 300 mg of florfenicol as an active substance.

Pharmacological activity:

Florfenicol is the active substance of the drug. Florfenicol belongs to enicol group and has a broad spectrum of antibacterial action against Actinobacillus pleuropneumoniae, Pasteurella multocida, Mannheimia haemolytica, Bordetella bronchiseptica, Haemophilus spp., Staphylococcus aureus, Streptococcus suis, Fusobacterium necrophorum, Bacteroides melaninogenicus, Moraxella bovis, Klebsiella pneumoniae, Streptococcus pneumoniae, Micrococcus spp.

In the protoplasm of a bacterial cell, florfenicol binds to the 70S ribosomal subunit and suppresses the enzyme peptidyl transferase, that results in the inhibition of protein synthesis in florfenicol-sensitive microorganisms. Florfenicol is also active against bacteria producing acetyltransferase and resistant to chloramphenicol.

When given via intramuscular or subcutaneous injection, florfenicol is quickly absorbed into the bloodstream and penetrates into almost all organs and tissues. The maximum concentration of florfenicol in the blood is reached in 1-2 hours after the drug administration. Being administered once, the therapeutic concentration of florfenicol in the body is maintained for 48 hours. Florfhenicol and its metabolites are excreted from the body mainly with urine and to a lesser extent with faeces.

Dosage:

Pigs: the drug is administered intramuscularly twice with an interval of 48 hours at a dose of 15 mg of florfenicol per 1 kg of body weight, which corresponds to 1 ml of florfenicol per 20 kg of body weight.

Cattle: the drug is administered intramuscularly twice with an interval of 48 hours at a dose of 20 mg of florfenicol per 1 kg of body weight, which corresponds to 1 ml of florfenicol per 15 kg of body weight. 

When given via subcutaneous injection, the preparation is administered once at a dose of 40 mg of florfenicol per 1 kg of body weight, which corresponds to 2 ml of preparation per 15 kg of body weight.

To minimize injection pain, the maximum volume of the preparation in one injection site should not exceed:

·       cattle - 10 ml,

·       pigs - 8 ml,

·       calves - 4 ml,

·       piglets - 2 ml.

Precautions and adverse reactions:

When used in accordance with the instruction, side effects and complications are generally not observed. After administration of the drug, redness and swelling of the tissues of the perianal area, soft feces may occur in some animals. These symptoms do not require treatment, pass quickly and do not affect the physiological state of the animals.

Do not use of the drug in animals with increased individual sensitivity to the components of the drug, as well as in animals with severe renal and hepatic insufficiency.

In case of overdose of the drug, animals may experience diarrhea and anorexia, an inflammatory reaction at the injection site. Reduced consumption of feed and water, slowed weight gain, in pigs – perianal erythema and edema my be noticed. These symptoms go away spontaneously without prescribing symptomatic remedies.

Do not use the drug simultaneously with amphenicols, penicillin group antibiotics, cephalosporins and fluoroquinolones in order to avoid side effects and complications. Do not mix the drug in one syringe with other medications.

After the first administration and cancellation, no peculiarities have been revealed.

Do not change the time intervals between the drug administration, it may lead to the decreased therapeutic concentration of florfenicol in the body. If the interval between two injections of the drug was increased, the treatment scheme should be restarted according to this instruction.

Do not use the drug in springer cows, farrowing sows, breeding boars and stud bulls.

Do not use in lactating animals that are used for milk production.

Withdrawal period:

Pigs must not be slaughtered for human consumption before 14 days, cattle – before 34 days after the last drug administration (intramuscular injection) and 42 days (subcutaneous injection). Meat of animals forcibly slaughtered earlier than the specified period expires may be used for feeding carnivores.

Storage conditions:

The drug should be stored in a dark place at a temperature between 2 °C to 25 °C. 

Shelf-life:

Shelf-life of the veterinary drug is 3 years from the date of manufacture. Shelf-life after the first opening of the bottle is 28 days under appropriate storage conditions.