Respiroflor-O 300

Therapeutic indications:

The drug is used for therapeutic purposes in pigs for actinobacillary pleuropneumonia, haemophilus polysorositis, bordetellosis, pasteurellosis, mycoplasmosis, salmonellosis, escherichiosis (colibacillosis), and other bacterial infections caused by microorganisms sensitive to florfenicol. In farm poultry (chickens: broilers, breeding poultry, parent flock poultry, and replacement young stock) for colibacillosis, salmonellosis, pasteurellosis, ornithobacteriosis, staphylococcosis, and other bacterial infections caused by microorganisms sensitive to florfenicol.

Pharmacotherapeutic group:

Amphenicols.

Dosage form description

Suspension for oral administration. In appearance, the drug is a white to light yellow suspension.

Polymer bottles of 1 l and canisters of 5 l.

Composition of the veterinary drug:

1 ml of the drug contains 300 mg of florfenicol as the active substance.

Pharmacological activity:

Florfenicol, the active substance of the drug, has a broad spectrum of antibacterial action against: Actinobacillus pleuropneumoniae, Pasteurella multocida, Mannheimia haemolytica, Bordetella bronchiseptica, Haemophilus spp., Mycoplasma hyopneumoniae, Mycoplasma hyorhinis, Ornithobacterium rhinotracheale, Escherichia coli, Salmonella spp., Staphylococcus spp., Streptococcus spp., Klebsiella spp., Proteus spp.

Florfenicol has a bacteriostatic effect on microorganisms sensitive to it. In the protoplasm of the bacterial cell, florfenicol binds to the 70S ribosomal subunit, blocks the enzyme peptidyl transferase, which leads to the inhibition of protein synthesis at the ribosomal level.

Upon oral administration of the drug, florfenicol is well absorbed from the gastrointestinal tract and penetrates into all organs and tissues, but does not cross blood-tissue barriers. The bioavailability of florfenicol after oral administration is 88% in pigs and 55% in poultry. The maximum concentration of the antibacterial agent in the blood is reached within 1–2 hours. The therapeutic concentration of the antibacterial agent is maintained in the organs and tissues of pigs and poultry for 24 hours. Florfenicol is excreted from the body of pigs primarily with urine and to a lesser extent with feces. Florfenicol is excreted from the body of poultry primarily with droppings.

Dosage:

The drug is administered orally to pigs with drinking water at a daily dose of 5 mg of florfenicol per 1 kg of animal body weight, which corresponds to 1 ml of the drug per 60 kg of animal body weight, for 7 days.

To poultry, the drug is administered orally at a daily dose of 20 mg of florfenicol per 1 kg of bird body weight (1 ml of the drug per 15 kg of bird body weight), which corresponds to about 0.5–1 l of the drug per 3000 l of drinking water, daily for 3 days, and for salmonellosis and mixed infections – for 5 days.

Before use, the bottle/canister with the drug should be shaken.

The drug is allowed to be used using pulse dosing.

Depending on the watering regimen and the settings of the dosing equipment, it is allowed to prepare both a therapeutic solution and use a stock working suspension.

To prepare the therapeutic solution, it is necessary to dilute the drug 300 times or more, since the active substance florfenicol dissolves at a concentration not exceeding 1 g/l, i.e., when diluting 1 l of the drug per 300 l of drinking water.

To prepare a stock working suspension for subsequent dosing, dissolution, and watering using dosing devices (pulse dosing), it is allowed to mix the drug with drinking water in any proportions, for example, 10 l of the drug and 10 l of water, 2 l of the drug and 50 l of water, or in other ratios. If necessary, the prepared stock working suspension is periodically (1 time within 2–6 hours) mixed.

The prepared therapeutic solution or stock working suspension should be used immediately after preparation and renewed every 24 hours during the course of treatment. During the therapy period, animals and poultry must receive only water containing the drug. In cases where this is impossible, for example, when using pulse dosing, the daily dose is administered over a period of at least 4 hours or divided into 2 equal parts and administered at an interval of 12 hours.

Contraindications:

Contraindicated for use in animals and poultry with hypersensitivity to the components of the drug. Do not use in animals with renal and hepatic insufficiency.

Overdose:

In case of overdose in animals and poultry, diarrhea and refusal of feed and water may be observed. In pigs, perianal erythema and edema. These symptoms disappear spontaneously without the prescription of symptomatic agents.

Pregnancy and lactation:

The drug is forbidden to be used in pregnant sows and lactating sows.

Special indications:

No special features of action upon the first application of the drug or upon its withdrawal have been identified. Skipping a scheduled application of the drug to animals and poultry should be avoided, as this may lead to a decrease in therapeutic efficacy. If administration of the drug is missed, the course of application must be resumed in accordance with the prescribed dose and treatment regimen. The missed application of the drug should not be compensated for by increasing the dose. It is forbidden to use the drug in breeding boars.

Side effects and individual intolerance:

Side effects and complications when using the drug in accordance with this instruction are generally not observed. In animals and poultry with hypersensitivity to the components of the drug, allergic reactions (edema, pruritus, dermatitis) may manifest. In this case, the use of the drug is discontinued, and antihistamines are prescribed and symptomatic treatment is carried out if necessary.

Withdrawal period:

Slaughter of pigs for meat is allowed no earlier than 14 days, and of poultry no earlier than 2 days after the last application of the drug. In case of forced slaughter of animals and poultry earlier than the specified period, the meat can be used for feeding carnivorous animals. The use of the drug is prohibited in poultry (during the egg-laying period) whose eggs are intended for human food, as well as in replacement young chickens less than 2 weeks before the start of egg laying.

Shelf-life:

2 years from the date of manufacture. It is forbidden to use the drug after the expiration date.

Storage conditions:

In a place protected from light at a temperature from 2 °C to 25 °C. The drug should be stored in a place inaccessible to children. After the first opening of the bottle/canister, 28 days subject to storage conditions. The prepared solution is valid for 24 hours.