Fluxirol

Therapeutic indications:

FLUXIROL is used in cattle and pigs as an anti-inflammatory, antipyretic, analgesic and antitoxic drug for the treatment of acute inflammatory processes and pain syndromes.

The drug is used as part of the complex therapy of musculoskeletal diseases (MSD) (arthrosis, arthritis, dislocations, edema (swelling), tendovaginitis, trauma, laminitis, muscle strain). The drug is used for the treatment of other diseases accompanied by the elevation of body temperature and in animals with pain syndromes of various etiologies (traumatic, postoperative, colic).

Composition of the veterinary drug:

1 ml of the preparation contains:

• 50 mg of flunixin meglumine as an active substance.

Pharmacological activity:

Flunixin meglumine is an active substance of the drug. Flunixin meglumine is a non-selective inhibitor of cyclooxygenases (COX-1 and COX-2).  Flunixin inhibits the production of prostaglandins E2, which causes inflammation, edema (swelling), pain syndrome and eleveation of body temperature, thus revealing its anti-inflammatory, analgesic and antipyretic effects.  Flunixin has an antitoxic effect against bacterial endotoxins.

After parenteral administration of the drug flunixin is rapidly absorbed from the injection site and penetrates into most organs and tissues. It accumulates in the inflammation area and reaches its maximum concentration in 5-45 minutes. The therapeutic effect of flunixin is maintained for 24-36 hours.  Flunixin is bind to plasma proteins to a considerable extent (up to 99%) and is excreted from the body mainly with faeces (about 80%) and to a lesser extent with urine.

Dosage:

The drug is administered to cattle via intravenous or intramuscular injection once a day at a dose of 2 ml of the drug per 45 kg of animal body weight (which corresponds to 2.22 mg of flunixin per 1 kg of animal body weight), until the affected cows completely recover, but not more than 5 consecutive days.

The drug is administered to pigs via intramuscular injection once (in the neck area at the base of the ear) at a dose of 2 ml of the drug per 45 kg of animal body weight (which corresponds to 2.22 mg of flunixin per 1 kg of animal body weight). If necessary, the injection of the same dose is repeated in 24 hours.

The drug should be injected slowly, preheated it to the body temperature of the animal.

Due to a possible severe pain reaction, do not inject intramuscularly more than 5 ml and 2,5 ml of the drug per injection site to large animals and small animals, respectively.

Precautions and adverse reactions:

When the drug is used in recommended doses and in accordance with all the instructions, side effects and complications are generally not observed. Some side effects (irritation in form of swelling) may occur in pigs at the injection site. These effects naturally disappears within 14 days.

In rare cases, symptoms of an allergic reaction such as hyperemia, itching, swelling may be observed. In this case the drug should be cancelled; antihistamines and other symptomatic treatment should be prescribed.

Do not use in animals with hypersensitivity to the components of the drug, as well as with severe heart diseases, kidneys and liver dysfunction, hypovolemia (with the exception of endotoxemia and septic shock) and when the risk of digestive gastrointestinal hemorrhage is high. Intra-arterial administration of the drug is prohibited.

Use drug with caution under the supervision of a veterinarian in cases of animal's dehydration, hypotension, concominant administration with general anesthetics, as well as in old animals. 

Symptoms of an overdose of the drug (indigestion, vomiting, acidosis) in an animal may occur. In these cases, detoxification and symptomatic therapy should be prescribed.

Do not use this drug simultaneously with other non-steroidal anti-inflammatory drugs, as well as within 24 hours before and 24 hours after their use.  Do not use the drug simultaneously with drugs with nephrotoxic properties. The drug should be used with caution when used along with general anesthesia, protein binding drugs (including anticoagulants) and sulfonamides.

After the first administration and cancellation, no peculiarities of the drug use have been revealed.

Avoid missing the next dose of the drug, as it may lead to the reduced therapeutic effect. If administration of the veterinary drug is missed, resume it in the same dosage and according to the same treatment scheme as soon as possible. Do not increase the dose to compensate the missing one.

Do not use the drug in pregnant females, young animals that are six weeks of age or younger and piglets weighing up to 6 kg.

Withdrawal period:

Cattle must not be slaughtered for human consumption before 8 days after the last intravenous injection and before 35 days after the last intramuscular injection; pigs – before 24 days after the last drug administration. Meat of animals forcibly slaughtered earlier than the specified period expires may be used for feeding carnivores.

It is forbidden to use milk for human consumption during the treatment period and within 5 days after the last drug administration. Milk obtained before the expiry of the established period is allowed for animal feeding after thermal treatment.

Storage conditions:

The drug should be stored in a dark place at a temperature between 2 °C to 25 °C. The drug should be kept out of reach of children.

Shelf-life:

Shelf-life of the veterinary drug is 3 years from the date of manufacture. Shelf-life after the first opening of the bottle is 28 days under appropriate storage conditions. Do not use the drug after the expiry date. Unused veterinary drug should be utilized in accordance with the requirements of the law.