Irmektel

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Veterinary drug IRMEKTEL


The drug is used for the treatment of various parasitic infections in cattle



  • A broad spectrum of antiparasitic activity (trematodes, nematodes, gadflies, lice, itch mites)

  • Highly effective against both internal (endo-) and external (ecto-) parasites

  • Single administration

  • Quickly absorbed

  • Easily penetrates into most organs and tissues

  • The therapeutic action lasts for 10-12 days


Therapeutic indications:

The veterinary drug is used for the treatment of fasciolosis, dictyocaulosis, haemonchosis, ostertagiosis, trichostrongylosis, cooperiosis, nematodirosis, bunostomosis, strongyloidosis, thelaziosis, hypodermatosis, oestrosis, sarcoptosis, oedemagenosis in cattle, sheep and deer.

Composition of the veterinary drug:

1 ml of the drug contains:

• 5 mg of ivermectin,

 • 125 mg of closantel (in the form of closantel sodium).

Pharmacological activity:

Irmektel is a combined drug, which is composed of ivermectin and closantel, with a broad-spectrum of antiparasitic activity against:     

  • Trematode – Fasciola hepatica, Fasciola gigantica;
  • Gastrointestinal and pulmonary nematodes – Bunostomum spp., Ostertagia spp., Oesophagostomum spp., Haemonchus spp., Trichostrongylus spp., Chabertia spp., Cooperia spp., Nematodirus spp., Strongyloides spp., Dictyocaulus spp., Thelazia spp. and others;
  • Gadflies – Hypoderma spp., Oestrus ovis;
  • Lice – Linognathus spp., Haematopinus spp. and others;
  • Itch mites – Psoroptes spp., Sarcoptes spp., Chorioptes spp.

The active substance of the drug is macrocyclic lactones ivermectin.  The drug enhances the release of gamma-aminobutyric acid (GABA) in presynaptic neurons, that leads to the disruption of the neuromuscular impulse conduction, paralysis and death of the parasite.

The active substance of the veterinary drug is salicylanilide closantel.  Affecting mitochondrial membranes, closantel inhibits the processes of oxidative phosphorylation, that leads to the decreased synthesis of adenosine triphosphoric acid (ATP) in mitochondria, disruption of energy metabolism and the death of the parasite.

After parenteral administration, the components of the drug are actively absorbed from the injection site and penetrate into most organs and tissues of the animal body.  The therapeutic concentration of ivermectin and closantel is maintained in the organism within 10-12 days since the last administration of the drug.

The drug is excreted from the organism in unchanged form with faeces and urine, in lactating animals - with milk.

The drug has a toxic effect on bees, fish and other aquatic organisms (hydrobionts).

Dosage:

The drug is given to cattle, sheep and deer via subcutaneous injection as a single dose of 1 ml per 50 kg of body weight, which corresponds to 0.1 mg of ivermectin and 2.5 mg of closantel per 1 kg of animal body weight.

In the case of sarcoptosis, the drug is administered twice with an interval of 7-14 days.

Due to the possible severe pain reaction, do not inject more than 10 ml per injection site.

Precautions and adverse reactions:

When given subcutaneously to cattle and deer, side effects such as tissue edema may be observed at the injection site within 7 days, in sheep – within 14 days after the last drug administration.  These symptoms disappear naturally.

In case of an overdose, side effects such as loss of appetite, tremor, increased salivation, visual impairment and diarrhea may be observed.  In these cases, the drug administration should be cancelled and, if necessary, symptomatic therapy is prescribed.

Do not use the drug simultaneously with other antiparasitic veterinary drugs.

Do not use in animals with hypersensitivity to the components of the drug.

Do not use the drug in animals, which are intended to produce milk for human consumption, in pregnant cows in the 1st third of pregnancy and less than 2 weeks prior to parturition.

Follow the rules of personal hygiene and safety while handling the drug.

Withdrawal period:

Cattle and deer must not be slaughtered for human consumption before 35 days, sheep – before 28 days after last drug administration.

Meat of animals forcibly slaughtered earlier than the specified period expires may be used for feeding carnivores.

Storage conditions:

The drug should be stored in a dark place at a temperature between + 2 °C to + 25 °C.

The drug should be kept out of reach of children.

Shelf-life:

Shelf-life of the veterinary drug is 18 months from the date of manufacture. Shelf-life after the first opening is 28 days under appropriate storage conditions.

It is prohibited to use the drug after its expiry date.

Unused veterinary drug should be utilized in accordance with the requirements of the law.

Available without prescription.

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