Vermectin zero

Therapeutic indications:

Veterinary drug VERMECTIN ZERO is indicated for for prevention and treatment of diseases in cattle, caused by both matured and larval stages of nematodes of gastrointestinal tract (Bunostomum sp., Cooperia sp., Haemonchus sp., Nematodirus sp., Oesophagostomum sp., Ostertagia sp., Trichostrongylus sp., Trichocephalus sp.) and lungs (Dictyocaulus), as well as by ixodid ticks, scabies mites, larvae of gadflies, fleas, lice and blood-sucking flies.

Composition of the veterinary drug:

1 ml Vermectin zero solution for injection contains:

• Eprinomectin 20 mg as an active substance;

Pharmacological activity:

The active substance of the veterinary drug is macrocyclic lactone eprinomectin.  Eprinomectin selectively interacts with specific receptors of muscle and nerve tissue of parasites and increases the permeability of membranes for chloride ions, which leads to disruption of the conductivity of nerve impulses, paralysis and death of parasites.

By subcutaneous administration, the bioavailability of eprinomectin is about 89%, the maximum concentration of eprinomectin is 58 mcg/l within 36–48 hours after injection. The half-life of the veterinary drug is 65-75 hours. Over 99% of eprinomectin binds to serum proteins and is excreted in unchanged form with feces.

Dosage:

The veterinary drug is administered for cattle by subcutaneous injection in a single dose of 1 ml /100 kg body weight (0.2 mg of eprinomectin/1 kg body weight).

VERMECTIN ZERO should be injected slowly. Before use heat the injection solution up to the body temperature of the animal.

Precautions and adverse reactions:

When using the drug in accordance with the instructions, side reactions and complications are generally not observed, however, in animals with increased individual sensitivity to the components of the drug, allergic reactions are possible. In case of allergic reactions, if necessary, antihistamines and symptomatic treatment are prescribed.

Do not use in animals, which are known to be hypersensitive to eprinomectin.

In case of the overdose of the veterinary drug, weakness, tremor and increased salivation may occur. There are no specific detoxification agents; general measures should be taken to remove the veterinary drug from the animal’s body.

The veterinary drug is approved for use in lactating and pregnant cows.

No special aspects of interaction with other veterinary drugs are revealed.

Eprinomectin is excreted in unchanged form with feces and has a toxic effect on the aquatic ecosystem. Therefore, keep treated animals away from water reservoirs for 2-4 weeks.

Withdrawal period:

Animals must not be slaughtered for human consumption within 21 days after the last treatment. Meat of animals forcibly slaughtered earlier than the specified period may be used for feeding carnivores. Milk for human consumption may be taken without limits.

Storage conditions:

Store in a dry, dark place at a temperature of 2º C to 25º C.

Shelf-life:

Shelf-life of the veterinary drug under appropriate storage conditions is 3 years from the date of manufacture. Shelf-life after first opening: 28 days.