Vermectin zero

Therapeutic indications:

The drug is prescribed for the treatment and prevention of gastrointestinal and pulmonary nematodiases in cattle; ectoparasitoses caused by ixodid and mange mites, botfly larvae, lice, fleas, and blood-sucking flies sensitive to eprinomectin.

Pharmacotherapeutic group:

Macrocyclic lactones.

Dosage form description

Solution for subcutaneous injection. In appearance, the drug is a transparent solution ranging from colorless to yellow.

Dark glass vials of 100 ml.

Composition of the veterinary drug:

1 ml of the drug contains 20 mg of eprinomectin as the active substance.

Pharmacological activity:

The drug is used in cattle for the treatment and prevention of diseases caused by imago and larval forms of gastrointestinal nematodes (Bunostomum spp., Cooperia spp., Haemonchus spp., Nematodirus spp., Oesophagostomum spp., Ostertagia spp., Trichostrongylus spp., Trichocephalus spp.) and pulmonary nematodes (Dictyocaulus), ixodid mites, mange mites, botfly larvae, fleas, lice, and blood-sucking flies.

The mechanism of antiparasitic activity of eprinomectin consists in selective binding to glutamate-gated chloride channel receptors located in the cell membranes of nerve and muscle cells, increasing their permeability to chloride ions and hyperpolarizing the membranes of nerve and muscle cells, which leads to disruption of nerve impulse conduction, paralysis, and death of parasites. Upon subcutaneous administration of the drug to cattle, the bioavailability of eprinomectin is about 89%, the maximum blood concentration of 58 µg/l is reached within 36–48 hours, and the half-life is 65–75 hours. More than 99% of eprinomectin binds to serum proteins and is excreted unchanged from the body, primarily with feces.

Dosage:

The drug is administered to cattle once subcutaneously at a dose of 1 ml per 100 kg of the animal's body weight, which corresponds to a dose of 0.2 mg of eprinomectin per 1 kg of the animal's body weight. The drug should be injected slowly after pre-warming to the animal's body temperature.

Contraindications:

Contraindicated for use in animals with increased individual sensitivity to eprinomectin.

Overdose:

In case of overdose, animals may exhibit weakness, tremor, and hypersalivation. Specific detoxification agents are absent; general measures aimed at eliminating the medicinal drug from the body are applied.

Pregnancy and lactation:

The drug is permitted for use in dairy and pregnant cows.

Special indications:

Eprinomectin, which is part of the drug and excreted unchanged with feces, has a toxic effect on the aquatic ecosystem. Therefore, treated animals are recommended to be kept away from water bodies for 2–4 weeks.

Side effects and individual intolerance:

Side effects and complications when using the drug in accordance with this instruction are generally not observed. In animals with increased individual sensitivity to the components of the drug, allergic reactions may occur. In this case, antihistamines are prescribed if necessary, and symptomatic treatment is performed.

Withdrawal period:

Slaughter of cattle for meat is permitted no earlier than 21 days after administration of the drug. In case of forced slaughter of animals earlier than the specified period, the meat can be used as feed for carnivorous animals. Milk from cows treated with the drug is permitted for food purposes without restrictions.

Shelf-life:

3 years from the date of manufacture. Use of the drug after the expiration date is prohibited.

Storage conditions:

In a place protected from light at a temperature from 2 °C to 25 °C. The drug should be stored in a place inaccessible to children. After the first opening of the vial – 28 days subject to storage conditions.