Mastocefur LC

Therapeutic indications:

The drug is used during lactation period for the treatment of clinical bovine mastitis caused by ceftiofur-sensitive microorganisms. 

Composition of the veterinary drug:

9 g of the preparation (one syringe) contains:

• 125 mg of ceftiofur hydrochloride as an active substance.

Pharmacological activity:

The drug contains ceftiofur, an antibacterial substance of the cephalosporin group. Ceftiofur is a semi-synthetic third-generation cephalosporin.

Ceftiofur has a broad spectrum of action against:  gram-negative and gram-positive bacteria, including Escherichia coli, Klebsiella spp., Corynebacterium spp., Streptococcus dysgalactiae, Streptococcus uberis, Streptococcus agalactiae, Staphylococcus aureus, and coagulase-negative staphylococcus (Staphylococcus xylosus, Staphylococcus warneri, Staphylococcus simulans), etc.

Ceftiofur inactivates penicillin-binding proteins involved in the synthesis of the main biopolymer of bacterial cell wall. Peptidoglycan (the main biopolymer) prevents reparation of pentidoglycan chains, that leads to the cell wall weakening and further bacteria lysis.

When administered via intramammary injection, ceftiofur is poorly absorbed from the injection site, that results in its high concentration in the udder tissues. Ceftiofur and its metabolites are mainly excreted from the animal's body with urine.

Dosage:

The drug is administered via intramammary injection into each quarter of the udder affected by mastitis at a dose of 9 g (one syringe) with an interval of 24 hours (not more than for 8 days), until the affected cows completely recover.

Before the drug administration, milk out the treated udder quarters; clean and disinfect the nipples with an antiseptic agent approved for this purpose (a cleaning disposable napkin). Carefully put the tip of the syringe in the nipple canal and squeeze out the syringe content. After the drug administration, remove the syringe, pinch the end of the nipple and massage the nipple upwards for better drug distribution.

Precautions and adverse reactions:

When the drug is used in recommended doses and in accordance with all the instructions, side effects and complications are generally not observed. In rear cases when an allergic reactions occur, the drug should be cancelled; antihistamines and calcium should be prescribed.

Do not use in animals with hypersensitivity to the components of the drug, as well as to cephalosporins and other beta-lactam antibiotics.

No overdose symptoms when using the drug have been observed.

MASTOCEFUR LC may be used simultaneously with other veterinary drugs except the drugs administered via intramammary injection.

Avoid missing the next dose of the drug, as it may lead to the reduced therapeutic effect. If administration of the veterinary drug is missed, resume it in the same dosage and according to the same treatment scheme as soon as possible. Keep the same interval between following doses further.

The drug may be used in pregnant cows.

Withdrawal period:

The withdrawal period for milk is 72 hours days after the last treatment. Milk collected from the healthy quarters before the expiry of the established period is allowed for animal feeding after thermal treatment. Milk from infected quarters should be desinfected by heating and then utilized.

Animals should not be slaughtered for human consumption within 24 hours after the last treatment.

Storage conditions:

Store in a dark place at a temperature between 15 °C to 25 °C.

The drug should be kept out of the reach of children.

Shelf-life:

Shelf-life of the veterinary drug under appropriate storage conditions is 2 years from the date of manufacture. Do not use the drug after the expiry date. Unused veterinary drug should be utilized in accordance with the requirements of the law.