Mastolexin

Therapeutic indications

The drug is used for the treatment of mastitis of bacterial etiology in cows, goats, sheep during the lactation period.

Composition of the veterinary drug

The 1 g of the drug contains:

•          350 mg of cephalexin monohydrate,

•          35 mg of gentamicin sulfate.

Pharmacological activity

MASTOLEXIN is highly effective against a broad spectrum of pathogenic microorganisms due to the combined effect of two antibiotics: cephalexin monohydrate and gentamicin sulfate.

The combination of cephalexin and gentamicin provides a wide range of antimicrobial activity of the drug against gram-positive and gram-negative microorganisms, such as Streptococcus spp. (including S. agalactiae), Staphylococcus spp. (including S. aureus), Salmonella spp., Escherichia coli, Proteus spp., Klebsiella spp., Campylobacter spp., Corynebacterium pyogenes.

Cephalexin is highly active against gram-positive bacteria. This antibiotic blocks cell wall synthesis by inhibiting the enzyme transpeptidase and causing osmotic imbalance and cell death.

Gentamicin sulfate is aminoglycoside antibiotic, which has a bactericidal effect on many gram-positive and gram-negative microorganisms. Gentamicin sulfate, actively penetrating through the cell membrane of bacteria, binds to the 30S subunit of bacterial ribosomes and inhibits the synthesis of the bacterial protein.

When administered via intramammary injection, the active substances gentamicin and cephalexin are rapidly distributed throughout the mammary gland and are almost not absorbed into the blood, do not undergo biotransformation in the body and are excreted mainly in unchanged form with milk.

Dosage

Before the drug administration, milk out the treated udder quarters. The udder skin and teats’ surface should be treated with an antiseptic solution. Carefully put the tip of the syringe in the nipple canal and squeeze out the syringe contents in the quarter of the udder affected by mastitis.

MASTOLEXIN is injected intramammary into each quarter of the udder affected by mastitis with an interval of 12-24 hours, but not more than 3 times:

 • Cows – 1 syringe-dispenser;

 • Sheep and goats – half of the syringe-dispenser.

After the drug administration, remove the syringe, pinch the end of the nipple and massage the nipple upwards during 1-2 minutes for better drug distribution.

Before use, warm the drug up to the body temperature of the animal.

Precautions and adverse reactions

When the drug is used in recommended doses and in accordance with all the instructions, side effects and complications are generally not observed. In case of an allergic reaction, the drug should be cancelled; antihistamines, calcium should be prescribed.

Overdose symptoms have not been identified in animals.

Do not use in animals with hypersensitivity to the components of the drug.

Use of this drug with other drugs is allowed, with the exception of drugs for intracisternal administration.

The peculiarities of the action of the drug during its first use and cancellation are not identified. If dose is missed, resume the drug use in the same dosage and according to the same treatment regimen.

Withdrawal period

The milk withdrawal period is 4 days after the last drug administration. It is forbidden to use milk before the mastitis symptoms complitelly disappear. Milk obtained before the expiry of the established period is allowed for animal feeding.  

Animals must not be slaughtered for human consumption before 5 days after the last drug administration. Meat of animals forcibly slaughtered earlier than the specified period expires may be used to feed carnivores.

Storage conditions

The drug should be stored in a dry, dark place, in the manufacturer's packaging at a temperature between + 2 °C to + 25 °C.

Shelf-life

Shelf-life of the veterinary drug is 3 (three) years from the date of manufacture.