Mastolexin

Therapeutic indications:

The drug is used in cows, sheep, and goats for mastitis of bacterial etiology during lactation.

Pharmacotherapeutic group:

Aminoglycosides in combinations.

Dosage form description

Suspension for intracisternal administration. In appearance, the drug is a suspension ranging from white-pink to yellowish in color.

Plastic syringes of 9.25 g, closed with caps.

Composition of the veterinary drug:

One syringe (9.25 g) contains 350 mg of cefalexin (in the form of cefalexin monohydrate), 35 mg of gentamicin (in the form of gentamicin sulfate) as active substances.

Pharmacological activity:

The combination of cefalexin and gentamicin, the active substances of the drug, provides a broad spectrum of antimicrobial activity against gram-positive and gram-negative microorganisms, including Streptococcus spp. (including S. agalactiae), Staphylococcus spp. (including S. aureus), Salmonella spp., Escherichia coli, Proteus spp., Klebsiella spp., Campylobacter spp., and Corynebacterium pyogenes.

Cefalexin is a cephalosporin group antibiotic with high activity against gram-positive bacteria. The mechanism of action of cefalexin involves inhibiting the activity of the transpeptidase enzyme, which is involved in binding the main component of the microbial cell wall peptidoglycan leading to disruption of the osmotic balance and cell death.

Gentamicin is an aminoglycoside group antibiotic with a broad spectrum of bactericidal action against gram-positive and gram-negative microorganisms. The mechanism of action of gentamicin involves inhibiting protein synthesis at the ribosomal level.

Following intracisternal administration of the drug, gentamicin and cefalexin are rapidly distributed throughout the mammary gland and are practically not absorbed into the bloodstream, do not undergo biotransformation in the body, and are excreted mainly unchanged in milk.

Dosage:

The drug is administered intracisternally to cows at a dose of 9.25 g (1 syringe), and to sheep and goats at 1/2 syringe into each affected quarter of the udder with an interval of 12–24 hours, not more than 3 times.

Before using the drug, the contents of the affected udder quarters are milked out, the teats are treated with an antiseptic agent (cleansing wipe) approved for these purposes, then the syringe cannula is inserted into the teat canal and the contents are gently squeezed out. After administration, the syringe cannula is removed, the tip of the teat is compressed with fingers for 1–2 minutes, and the teat is lightly massaged from bottom to top for better distribution of the drug.

Before use, it is recommended to warm the drug to the animal's body temperature.

Contraindications:

Contraindicated for use in animals with increased individual sensitivity to the components of the drug.

Overdose:

Symptoms of overdose upon use of the drug in animals have not been identified.

Pregnancy and lactation:

The drug is used during lactation. The use of the drug in pregnant animals is not contraindicated.

Special indications:

No special features of action were identified upon the first use of the drug or upon its withdrawal. Missing a scheduled administration of the drug to animals should be avoided, as this can lead to a decrease in therapeutic efficacy. If a dose is missed, the course of administration must be resumed in accordance with the prescribed dose and treatment regimen. A missed administration should not be compensated by increasing the dose.

Side effects and individual intolerance:

Side effects and complications are generally not observed when using the drug in accordance with these instructions. In the event of allergic reactions, use of the drug is discontinued, and antihistamines and calcium preparations are prescribed.

Withdrawal period:

Slaughter of animals for meat is permitted no earlier than 5 days after the last administration of the drug. The meat of animals forcibly slaughtered before the expiration of this period may be used to feed carnivorous animals. The use of milk for human consumption is permitted no earlier than 4 days after the last administration of the drug, provided complete clinical recovery is achieved. Milk obtained earlier than the established period may be used to feed animals after boiling.

Shelf-life:

3 years from the date of manufacture. Use of the drug after the expiration date is prohibited.

Storage conditions:

In a place protected from light at a temperature from 2 °C to 25 °C. The drug should be stored in a place out of the reach of children. After opening the packaging, the drug is not subject to storage.