Sutrimet-Lite

Therapeutic indications:

The drug is administered with therapeutic purpose to calves with colisepticaemia, salmonellosis, pasteurellosis, bronchopneumonia, staphylococcosis, streptococcosis; pigs with escherichiosis (colibacillosis), infectious atrophic rhinitis, salmonellosis, pasteurellosis, toxoplasmosis, haemophilus pleuropneumonia; broiler chickens and repair poultry in case of colisepticaemia, pasteurellosis, escherichiosis (colibacillosis), salmonellosis, staphylococcosis, eimeriosis.

Composition of the veterinary drug:

1 ml of the drug contains as active ingredients:

• 400 mg of sulfadimidine (sulfadimesin) (in the form of sulfadimidine sodium),
• 80 mg trimethoprim.

Pharmacological activity:

The drug belongs to the medicines of the sulfonamides group, which have antibacterial and antiprotozoal action.

Sulfadimidine and trimethoprim have a wide spectrum of action against most Gram-positive and Gram-negative microorganisms, including Streptococcus spp., Staphylococcus spp., Escherichia coli, Salmonella spp., Pasteurella spp., Haemophilus spp., Bordetella spp., as well as some protozoa, such as Eimeria spp., Toxoplasma gondii.

The mechanism of action of sulfadimidine is to disrupt the synthesis of dihydrofolic acid in bacterial cells, preventing the inclusion of para-aminobenzoic acid in its molecule.

Trimethoprim enhances the action of sulfadimidine by disrupting the reduction of dihydrofolic acid into tetrahydrofolic acid, the active form of folic acid responsible for protein metabolism and microbial cell division. When combined, they disrupt the synthesis of folic acid at two consecutive stages, which leads to disruption of nucleotide synthesis and determines the synergistic bactericidal effect of the combination of sulfadimidine and trimethoprim.

Active substances of the drug are rapidly absorbed from the gastrointestinal tract and penetrate into all organs and tissues of the body. Therapeutic concentration of sulfadimidine and trimethoprim is maintained for 24 hours. Excreted from the body mainly with urine, to a lesser extent - with bile.

Dosage:

The drug is administered orally individually or in groups with drinking water in the following doses:

• calves, pigs - 1-2 ml of the drug per 32 kg of animal body weight within 5 days;
• poultry - in case of diseases of bacterial etiology - 1-2 ml of the drug per 32 kg of body weight of poultry within 5 days; in case of eimeriosis 0,2-0,3 ml of the drug per 1 kg of body weight of poultry (corresponds to 100 ml of the drug per 100 litres of drinking water) within 3-5 days.

Before use, bottle/canister with concentrate should be thoroughly shaken until homogeneous suspension is obtained.

The preparation may be applied using a pulse-dosing technique.

Depending on the dosing mode and settings of dosing equipment, it is allowed to prepare both therapeutic solution and use mother working suspension.

It is allowed to mix the drug with drinking water in any proportions, if subsequent dosing, dissolving and drinking are performed with the help of dosing devices (pulse-dosing). If necessary, shake mother working suspension of the drug periodically (once in 6-12 hours).

Shelf life of the drug after mixing with water is 24 hours. During the treatment period at group method of administration, water containing the drug should be the only source of drinking. If it is impossible, the daily dose is given for at least 4 hours or divided into 2 equal parts and given at an interval of 12 hours.

In case of individual method of administration the daily dose of the drug should be divided into two equal parts and given to animals in two doses, 12 hours apart.

Precautions and adverse reactions:

Adverse reactions are usually not observed. In animals with increased individual sensitivity to the components of the drug, allergic reactions are possible. In this case, the use of the drug is discontinued, antihistamines are prescribed. Treat symptomatically.

Do not use in animals and poultry with impaired renal and liver function, laying hens, as well as with increased individual sensitivity to the components of the drug.

Overdose symptoms of in animals and poultry have not been revealed.

Do not use of the drug simultaneously with para-aminobenzoic acid derivatives, such as local anesthetics: procaine, tetracaine and procainamide. Also, the drug should not be used with B vitamins (nicotinamide, folic acid, choline) due to their antagonistic effect on sulfonamides.

After the first administration and cancellation, no peculiarities of the drug use are revealed.

Avoid missing the next dose of the drug, as it may lead to the reduced therapeutic effect. If administration of the veterinary drug is missed, resume it in the same dosage according to the same treatment scheme as soon as possible. Do not use a higher doses to offset a missed one.

No special aspects of the drug use during pregnancy and lactation have been identified. In these cases, the drug is used under the supervision of a veterinarian.

The preparation must not be used for poultry, whose egg is used for human consumption.

Withdrawal period:

Animals should not be slaughtered for human consumption within 10 days after the last treatment; poultry in the treatment of eimeriosis should not be slaughtered for human consumption before 10 days, and in the treatment of diseases of bacterial etiology - not earlier than 5 days after the last use of the drug. Meat of animals and poultry forcibly slaughtered earlier than the specified period expires may be used for feeding carnivores.

Storage conditions:

Store in a dark place at a temperature between +2°C to +25°C. The drug should be kept out of the reach of children.

Shelf-life:

Shelf-life of the veterinary drug is 3 years from the date of manufacture. Shelf-life after the first opening of the bottle is 6 month under appropriate storage conditions. The prepared working solution should be used within a day. Do not use the drug after the expiry date.