Sutrimet-forte

Therapeutic indications:

The drug is administered to pigs and poultry (broilers, breeding poultry, poultry of parental flock, repair young chickens) for treatment of diseases of bacterial, mycoplasma and protozoal etiology (salmonellosis, pasteurellosis, hemophilosis, escherichiosis (colibacillosis), dysentery, ileitis, clostridiosis, streptococcosis, mycoplasmosis, actinobacillus pleuropneumonia of pigs and others; pasteurellosis, salmonellosis, escherichiosis (colibacillosis), clostridiosis, mycoplasmosis, staphylococcosis, eimeriosis in poultry), the pathogens of which are sensitive to the active ingredients of the drug.

Composition of the veterinary drug:

1 ml of the drug contains as active ingredients:

• 100 mg sulfadimidine,
• 20 mg trimethoprim,
• 100 mg lincomycin hydrochloride,
• 800 000 IU colistin sulfate (equivalent to 33 mg)

Pharmacological activity:

SUTRIMET-FORTE is a combined drug with antibacterial and antiprotozoal action.

Sulfadimidine and trimethoprim have a broad spectrum of action against most Gram-positive and Gram-negative microorganisms, including Streptococcus spp., Staphylococcus spp., Escherichia coli, Shigella spp. and others, as well as some protozoa, such as Eimeria spp., Toxoplasma gondii.

Lincomycin is produced by Streptomyces lincolnensis, has bacteriostatic effect. It has a wide spectrum of antibacterial action, effective against Staphylococcus spp., Streptococcus spp. (including those producing penicillinase), Corynebacterium spp., Clostridium spp., Brachyspira hyodysenteriae, Bacteroides spp., Actinomyces spp. as well as Mycoplasma spp. and Haemophilus influenzae.

Colistin has bactericidal activity against Gram-negative bacteria such as Escherichia coli, Salmonella spp., Pasteurella spp., Bordetella spp., Klebsiella spp., Pseudomonas aeruginosa and others.

Sulfadimidine disrupts the synthesis of dihydrofolic acid in bacterial cells, preventing the incorporation of para-aminobenzoic acid into its molecule. In turn, trimethoprim, enhances the effect of sulfadimidine, disrupting the reduction of dihydrofolic acid into tetrahydrofolic acid - the active form of folic acid, responsible for protein metabolism and division of the microbial cell. In the combined action of sulfadimidine and trimethoprim, the synthesis of folic acid is disrupted at two consecutive stages, which leads to disruption of nucleotide synthesis and causes synergistic bactericidal action.

The mechanism of action of lincomycin is based on inhibition of ribosomal protein synthesis due to the binding of the antibiotic to the 50S-subunit and disruption of the formation of peptide bonds.

The antimicrobial effect of colistin is to disrupt the permeability of the cytoplasmic membrane, which leads to its destruction and lysis of the bacterial cell.

Sulfadimidine, trimethoprim, lincomycin are absorbed from the gastrointestinal tract and penetrate into all organs and tissues of the body. Therapeutic concentration of sulfadimidine and trimethoprim is maintained for 24 hours. The maximum concentration of lincomycin in the blood is reached 2-4 hours after administration of the drug. Colistin in the gastrointestinal tract of animals and poultry is not degraded by enzymes and is practically not absorbed into the blood, thus creating its high concentration; it does not accumulate in organs and tissues.

Sulfadimidine and trimethoprim are excreted mainly with urine, to a lesser extent - with bile, lincomycin - unchanged mainly with urine and feces, colistin - unchanged with feces.

Dosage:

The drug is administered orally to individual animal or in groups with drinking water to pigs and poultry at a dose of 500-750 ml/t water or 1-2 ml per 10 kg of body weight during 3-5 days.

Before application the bottle/canister with the drug should be shaken.

The drug may be administered with the use of pulse-dosing. Depending on the mode of drinking and settings of dosing equipment it is allowed to prepare both therapeutic solution and use stock working suspension. When using the drug with subsequent dosing, dissolution and drinking with the help of dosing devices (pulse-dosing), it is allowed to mix it with drinking water in any proportions, for example, 10 liters of the drug and 10 liters of water, 2 liters of the drug and 50 liters of water or in other ratios. The prepared drug working suspension shall be mixed periodically (once within 2-6 hours).

Shelf life of the drug after dilution with water is 24 hours.

During the treatment period, water containing the drug should be the only source of drinking. In case when it is impossible, the daily dose is divided into parts and administered at a minimum intervals.

Precautions and adverse reactions:

Adverse reactions are usually not observed. In animals and poultry with increased individual sensitivity to the components of the drug, allergic reactions are possible. In this case, the use of the drug is discontinued and antihistamines are prescribed and symptomatic treatment is given.

Do not use in animals and poultry with impaired renal function, as well as with increased individual sensitivity to the components of the drug.

In case of drug overdose, animals and poultry may experience depression, diarrhea, anorexia, vomiting, nephrotoxic effects.

Do not use the drug simultaneously with ionophoric coccidiostatics, aminoglycosides, rifampicin, salicylates, butadione, naproxen and para-aminobenzoic acid derivatives, as well as other antibacterial drugs.

After the first administration and cancellation, no peculiarities of the drug use are revealed.

Avoid missing the next administration of the drug to animals and poultry, as it may lead to decrease of therapeutic efficacy. If administration of the veterinary drug is missed, resume it in the same dosage according to the same treatment scheme as soon as possible. Do not use a higher doses to offset a missed one.

Use with caution in gestating and lactating sows.

The drug must not be used for poultry, whose egg is used for human consumption.

Withdrawal period:

Animals should and poultry not be slaughtered for human consumption within 10 days after the last treatment. Meat of animals and poultry forcibly slaughtered earlier than the specified period expires may be used for feeding carnivores.

Storage conditions:

Store in a dark place at a temperature between +2°C to +25°C. The drug should be kept out of the reach of children.

Shelf-life:

Shelf-life of the veterinary drug is 2 years from the date of manufacture. Shelf-life after the first opening of the bottle is 28 days under appropriate storage conditions. The prepared working solution should be used within a day. Do not use the drug after the expiry date. Unused veterinary drug should be utilized in accordance with the requirements of the law. Available without prescription.