Sutrimet-forte

Therapeutic indications:

The drug is prescribed for pigs and poultry (broilers, breeding birds, parent stock, replacement pullets) for treatment of diseases of bacterial, mycoplasmal, and protozoal etiology (salmonellosis, pasteurellosis, hemophilosis, escherichiosis (colibacillosis), dysentery, ileitis, clostridiosis, streptococcosis, mycoplasmosis, actinobacillary pleuropneumonia in pigs, and others; pasteurellosis, salmonellosis, escherichiosis (colibacillosis), clostridiosis, mycoplasmosis, staphylococcosis, eimeriosis in poultry), caused by pathogens sensitive to the active substances of the drug.

Pharmacotherapeutic group:

Other antibacterial agents in combinations.

Dosage form description

Oral suspension. In appearance, the drug is a suspension from white to light yellow.

Polymer bottles of 1 L and canisters of 5 L.

Composition of the veterinary drug:

1 ml of the drug contains 100 mg of sulfadimidine, 20 mg of trimethoprim, 100 mg of lincomycin hydrochloride, and 800,000 IU of colistin sulfate (equivalent to 33 mg) as active substances.

Pharmacological activity:

Sulfadimidine and trimethoprim have a broad spectrum of activity against most Gram-positive and Gram-negative microorganisms, including Streptococcus spp., Staphylococcus spp., Escherichia coli, Shigella spp., and others, as well as some protozoa such as Eimeria spp. and Toxoplasma gondii.

Lincomycin is produced by Streptomyces lincolnensis and has a bacteriostatic effect. It has a broad spectrum of antibacterial action against Gram-positive bacteria (including Staphylococcus spp., Corynebacterium spp., Clostridium spp., Brachyspira hyodysenteriae, Bacteroides spp., Actinomyces spp., and Mycoplasma spp., Haemophilus influenzae, and Streptococcus spp, Staphylococcus spp. that produce penicillinase.

Colistin has bactericidal activity against Gram-negative bacteria such as Escherichia coli, Salmonella spp., Pasteurella spp., Bordetella spp., Klebsiella spp., Pseudomonas aeruginosa, and others.

The mechanism of action of sulfadimidine involves disrupting the synthesis of dihydrofolic acid in bacterial cells by preventing the incorporation of para-aminobenzoic acid into its molecule. Trimethoprim, in turn, enhances the effect of sulfadimidine by disrupting the reduction of dihydrofolic acid to tetrahydrofolic acid – the active form of folic acid responsible for protein metabolism and microbial cell division.

The combined action of sulfadimidine and trimethoprim disrupts folic acid synthesis at two sequential stages, leading to impaired nucleotide synthesis and resulting in synergistic bactericidal action. The mechanism of lincomycin action is based on inhibiting protein synthesis at the ribosomal level due to the binding of the antibiotic to the 50S subunit and disruption of peptide bond formation. The antimicrobial action of colistin involves disrupting the permeability of the cytoplasmic membrane, leading to its destruction and lysis of the bacterial cell. Sulfadimidine, trimethoprim, and lincomycin are absorbed from the gastrointestinal tract and penetrate into all organs and tissues...

Dosage:

The drug is administered orally, individually or to groups, with drinking water to pigs and poultry at a dose of 500–750 ml/t of water or 1–2 ml per 10 kg of body weight for 3–5 days.

Before use, shake the bottle/canister with the drug.

The drug can be administered using pulse dosing.

Depending on the watering system and dosing equipment settings, it is permissible to prepare either a therapeutic solution or a stock working suspension.

When using the drug with subsequent dosing, dissolution, and watering via dosing devices (pulse dosing), it can be mixed with drinking water in any proportion, e.g., 10 L of drug and 10 L of water, 2 L of drug and 50 L of water, or in other ratios. The prepared stock working suspension of the drug should be stirred periodically (every 2–6 hours).

During therapy, water containing the drug should be the only source of drinking water. If this is not possible, the daily dose should be divided into parts and administered at minimum intervals.

Contraindications:

Do not administer to animals and poultry with increased individual sensitivity to the drug components, as well as with severe renal insufficiency.

Overdose:

In case of drug overdose, animals and poultry may experience depression, diarrhea, anorexia, vomiting, and nephrotoxic effects.

Pregnancy and lactation:

Administer the drug to pregnant and lactating sows with caution.

Special indications:

No specific effects have been observed upon first use or discontinuation of the drug. Avoid missing subsequent doses of the drug for animals and poultry, as this can lead to a decrease in therapeutic efficacy. If a dose is missed, resume the course of administration according to the prescribed dose and regimen. Do not compensate for a missed dose by increasing the dose. Do not administer the drug to boars intended for breeding.

Side effects and individual intolerance:

Side effects and complications are generally not observed when the drug is used according to these instructions. In animals and poultry with increased individual sensitivity to the drug components, allergic reactions may occur. In such cases, discontinue the use of the drug, and if necessary, prescribe antihistamines and symptomatic treatment.

Interaction with other veterinary medicinal products:

Do not administer the drug simultaneously with ionophore coccidiostats, aminoglycosides, rifampicin, salicylates, butadione, naproxen, and para-aminobenzoic acid derivatives, as well as other antibacterial drugs.

Withdrawal period:

Slaughter of animals and poultry for meat is allowed no earlier than 10 days after the last administration of the drug. In case of forced slaughter of animals and poultry before the specified period, meat can be used for feeding carnivorous animals. Do not administer the drug to poultry whose eggs are intended for human consumption.

Shelf-life:

2 years from the date of production. The use of the drug after its expiration date is prohibited.

Storage conditions:

In a place protected from light at a temperature from 2 °C to 25 °C. The drug should be stored out of reach of children. After the first opening of the bottle/canister – 28 days under storage conditions. The prepared solution is valid for 24 hours.