Lincomycin-P 200

Therapeutic indications:

The drug is used for the treatment of pigs and poultry (broiler chickens, replacement pullets of laying hens) for diseases caused by microorganisms sensitive to lincomycin, including enzootic pneumonia and swine dysentery, necrotic enteritis, avian mycoplasmosis, musculoskeletal disorders, and bacterial complications of viral infections accompanied by respiratory tract damage.

Pharmacotherapeutic group:

Lincosamides.

Dosage form description

Powder for oral administration and preparation of oral solution. In appearance, the drug is a white to light yellow powder.

Metallized polymer film packages of 1 kg and multi-layer paper bags with polyethylene coating (liner) of 25 kg.

Composition of the veterinary drug:

1 g of the drug contains 200 mg of lincomycin hydrochloride as the active substance, and glucose as an excipient.

Pharmacological activity:

Lincomycin, the active substance of the drug, is produced by Streptomyces lincolnensis and has a bacteriostatic effect. It is effective against Staphylococcus spp., Streptococcus spp. (including penicillinase-producing strains), Corynebacterium spp., Clostridium spp., Brachyspira hyodysenteriae, Bacteroides spp., Actinomyces spp., as well as Mycoplasma spp. and Haemophilus influenzae. The mechanism of action of lincomycin consists in inhibiting protein synthesis at the ribosomal level due to the binding of the antibiotic to the 50S subunit and disruption of peptide bond formation. Lincomycin is well absorbed from the gastrointestinal tract and penetrates all organs and tissues of animals and birds. The maximum blood concentration is achieved 2–4 hours after application. It is excreted from the body unchanged primarily with urine (up to 14%) and feces (up to 75%).

Dosage:

The drug is administered orally mixed with feed or drinking water in the following daily doses:

• for pigs: 0.025–0.05 g of the drug per 1 kg of animal body weight (equivalent to 1–2 g of the drug per 40 kg of animal body weight), or 750–1500 g of the drug per 1 ton of feed, or 225–450 g of the drug per 1 ton of drinking water for 3–5 days; for enzootic (mycoplasmal) pneumonia and dysentery for 10–14 days;
• for poultry: 0.015–0.03 g of the drug per 1 kg of bird body weight (equivalent to 1.5–3 g of the drug per 100 kg of bird body weight), which amounts to 100–400 g of the drug per 1 ton of feed or 50–200 g of the drug per 1 ton of drinking water for 3–5 days; for mycoplasmosis for 10–14 days; for necrotic enteritis for 7 days.

During the treatment period, the prepared solution must be the sole source of drinking water for animals and birds.

The aqueous solution of the drug is prepared daily in an amount calculated for consumption within 24 hours.

The drug is thermally stable and does not lose its properties during heat treatment for 15 minutes at a temperature of 100 °C.

Contraindications:

Contraindicated for use in animals and birds with increased individual sensitivity to the components of the drug, as well as in liver and kidney disorders. Use in horses, ruminants, and rabbits is strictly prohibited.

Overdose:

In case of overdose, gastrointestinal dysfunction and decreased feed intake may be observed in animals and birds. In this case, the drug is discontinued and symptomatic treatment is prescribed. There are no specific antidotes.

Pregnancy and lactation:

It is prohibited to use the drug in animals during pregnancy and lactation.

Special indications:

At the beginning of treatment in pigs, diarrhea and/or rectal mucosal edema may occur; skin redness is possible in rare cases. These signs disappear within 5–8 days without discontinuing the drug. No specific effects of the drug upon discontinuation have been identified. Skipping an administration of the drug to animals and birds should be avoided, as this may lead to a decrease in therapeutic efficacy. If a dose is missed, the course of treatment should be resumed in accordance with the prescribed doses and treatment regimen. Do not compensate for a missed application by increasing the dose.

Side effects and individual intolerance:

Adverse reactions and complications are generally not observed when using the drug in accordance with these instructions. In animals and birds with increased individual sensitivity to the components of the drug, allergic reactions and the development of dysbiosis are possible. In this case, the use of the drug is discontinued, antihistamines are prescribed if necessary, and symptomatic treatment is carried out.

Withdrawal period:

Slaughter of pigs for meat is permitted no earlier than 10 days, and poultry no earlier than 3 days after the application of the drug. In the case of forced slaughter of animals and birds earlier than the specified period, the meat may be used as feed for carnivorous animals. It is prohibited to use the drug in poultry whose eggs are intended for human consumption.

Shelf-life:

2 years from the date of manufacture. It is prohibited to use the drug after the expiration date.

Storage conditions:

In the manufacturer's packaging in a dark place at a temperature from 2 °C to 25 °C. The drug should be stored in a place inaccessible to children. After first opening the package: 3 months under storage conditions. The prepared solution is valid for 24 hours.