Respiroflor-O 100

Therapeutic indications:

The drug is used for therapeutic purposes in agricultural poultry (broilers, parent stock, replacement pullets) and pigs for colibacillosis (escherichiosis), pasteurellosis, salmonellosis, streptococcosis, mycoplasmosis, chronic respiratory diseases, necrotic enteritis, infectious atrophic rhinitis, and swine dysentery, as well as other diseases of bacterial etiology whose causative agents are sensitive to enrofloxacin and gentamicin.

Pharmacotherapeutic group:

Naphthyridine derivatives, quinolones, fluoroquinolones in combinations.

Dosage form description:

Oral solution. In appearance, the drug is a transparent solution ranging from light yellow to dark yellow in color. Polymer bottles of 1 L and canisters of 5 L.

Composition of the veterinary drug:

1 ml of the drug contains 100 mg of enrofloxacin and 50 mg of gentamicin sulfate as active substances.

Pharmacological activity:

Enrofloxacin and gentamicin, which are active substances of the drug, exhibit synergism, thereby enhancing the antimicrobial effect and expanding the spectrum of activity of the drug. The combination of active substances is highly active against gram-negative bacteria (Escherichia coli, Enterobacter spp., Klebsiella spp., Salmonella spp., Proteus spp., Campylobacter spp., Pseudomonas aeruginosa, Bordetella spp., Pasteurella spp., Haemophilus spp., Actinobacillus spp., Brucella spp., Brachyspira hyodysenteriae) and gram-positive bacteria (Clostridium spp., Streptococcus spp., Staphylococcus spp., including beta-lactamase-producing strains), as well as against Mycoplasma spp., Chlamydia spp., and Ureaplasma spp.

The mechanism of the bactericidal action of enrofloxacin consists in inhibiting the activity of the gyrase enzyme, which affects DNA helix replication in the bacterial cell. Enrofloxacin is well absorbed from the gastrointestinal tract, rapidly distributes throughout the body, and its concentration in organs and tissues exceeds the blood level by 2–3 times. Particularly high concentrations of enrofloxacin are observed in the lungs, liver, kidneys, bones, and lymphatic system. In the body, enrofloxacin is partially metabolized to form the active metabolite ciprofloxacin, and is excreted mainly with urine and bile, and in lactating females – with milk.

The mechanism of action of gentamicin consists in suppressing protein synthesis in the bacterial cell at the ribosomal level. Upon oral administration, gentamicin is poorly absorbed through the intact intestinal wall; when the intestinal mucosa is damaged due to an inflammatory process, the absorption of gentamicin increases. Gentamicin is excreted from the body unchanged, mainly with feces. The maximum concentration of the drug in the blood is achieved in 1.5–2 hours and persists for 6 hours, while the therapeutic concentration persists for 24 hours after administration.

Dosage:

The drug is administered orally for 3–5 days in the following doses:

• agricultural poultry individually or in a group method with drinking water at 0.5–1 ml of the drug per 1 liter of water or 0.1 ml of the drug per 1 kg of the bird's body weight, depending on the severity of the pathological process. In mixed infections, as well as in chronic forms of diseases, the course of treatment can be extended up to 7 days
• pigs individually or in a group method at 5 ml of the drug per 100 kg of the animal's body weight with drinking water. In the treatment of dysentery, the dose of the drug must be increased to 10 ml of the drug per 100 kg of the animal's body weight.

The prepared solution should be used during the day. The solution of the drug should be prepared daily. During the therapy period, water containing the drug must be the only source of drinking.

Contraindications:

The use of the drug is contraindicated in animals and poultry with increased individual sensitivity to the components of the drug, as well as with severe hepatic and/or renal insufficiency.

Overdose:

In case of overdose of the drug in animals and poultry, excitation that is replaced by sharp depression, rapid breathing, and palpitations may be observed. With prolonged use in piglets, arthropathy may occur. In these cases, it is necessary to discontinue the use of the drug and, if necessary, carry out symptomatic therapy.

Pregnancy and lactation:

The use of the drug is prohibited in pregnant and lactating sows.

Special indications:

No special features of action during the first application of the drug and upon its withdrawal were identified. It is necessary to avoid skipping a regular application of the drug to animals and poultry, as this can lead to a decrease in therapeutic efficacy. If an application of the drug is missed, the course of administration must be resumed in accordance with the prescribed dose and treatment regimen. Do not compensate for a missed application of the drug by increasing the dose.

Side effects and individual intolerance:

Side effects and complications when using the drug in accordance with this instruction are generally not observed. In animals with increased individual sensitivity to the components of the drug, convulsions, tremor, vomiting, anorexia, and hemolytic anemia may occur. In this case, the use of the drug is discontinued, and antihistamines and symptomatic therapy agents are prescribed to the animal.

Interaction with other veterinary medicinal products:

It is not recommended to use the drug concomitantly with bacteriostatic antibiotics (macrolides, tetracyclines) due to the possible antagonistic effect, as well as with theophylline, polyether ionophores, non-steroidal anti-inflammatory drugs, magnesium, and calcium drugs.

Withdrawal period:

Slaughter of animals and poultry for meat is permitted no earlier than 14 days after the last application of the drug. In the case of forced slaughter of animals earlier than the specified period, the meat can be used to feed carnivores. The use of the drug is prohibited for poultry whose eggs are used for human food, as well as for replacement pullets of chickens less than 2 weeks before the start of egg-laying.

Shelf-life:

2 years from the date of manufacture. It is forbidden to use the drug after the expiration date.

Storage conditions:

In a dry place protected from light at a temperature from 2 °C to 25 °C. The drug should be stored in a place inaccessible to children. After the first opening of the bottle/canister – 28 days subject to storage conditions. The prepared solution is stable for 24 hours.