BAG-Amoxicillin LA

Therapeutic indications:

Veterinary drug BAG-Amoxicillin LA  is used in large and small livestock, pigs, carnivores to treat infectious diseases of the respiratory (including bronchitis, bronchopneumonia, rhinitis), digestive (including gastroenteritis, enterocolitis) and urogenital (including metritis, mastitis, endometritis, cystitis, urethritis, pyelonephritis) as well as for skin and wound infections, peritonitis and other diseases caused by microorganisms sensitive to amoxicillin.

Composition of the veterinary drug:

1 ml BAG-Amoxicillin LA suspension for injection contains:

• 150 mg of amoxicillin trihydrate

Pharmacological activity:

The active substance of the veterinary drug is amoxicillin, which is a semi-synthetic antibiotic from the group of penicillins with a broad spectrum of bactericidal activity.

Pathogens that are sensitive to amoxicillin are listed below: Bacteroides spp., Brucella spp., Campylobacter spp., Clostridium spp.,Corynebacterium spp., Erysipelothrix rhusiopathiae, Escherichia coli, Fusobacterium necrophorum, Haemophilus spp., Proteus spp., Salmonella spp., Streptococcus spp., Staphylococcus spp., etc., except  β-lactamase-producing strains. 

The bactericidal mechanism of action of amoxicillin is based on inhibiting the activity of the enzyme transpeptidase, which leads to disruption of cell wall synthesis and destruction of the bacterial cell.

After intramuscular administration of the drug, the maximum concentration of amoxicillin in the blood is reached within 1–2 hours and remains at therapeutic levels for up to 48 hours. Amoxicillin is excreted from the body primarily by the kidneys and partially by the liver in unchanged form.

Dosage:

The drug is administered once intramuscularly at a dose of 1 ml per 10 kg of animal body weight, which corresponds to 15 mg of amoxicillin trihydrate per 1 kg of animal body weight. If necessary, the injection is repeated after 48 hours. Do not inject more than 20 ml of the drug at a single site for cattle, 10 ml for pigs, and 5 ml for calves, goats, sheep, and carnivores.

Before use, the vial with the drug should be thoroughly shaken until a homogeneous suspension is obtained.

Contraindications:

Do not use the drug in animals with impaired renal excretory function, as well as in cases of increased individual sensitivity to the components of the drug.

Overdose:

In case of drug overdose, gastrointestinal disorders, refusal of food, vomiting, impaired coordination of animal movements, and swelling at the injection site may occur.

Pregnancy and lactation:

The drug can be used in females during pregnancy and lactation.

Special indications:

No specific effects of the drug upon first use or upon its cancellation have been identified.

Side effects and individual intolerance:

As a rule, no adverse effects or complications are observed when the drug is used in accordance with these instructions. Allergic reactions are possible in animals with increased individual sensitivity to penicillins or cephalosporins. In the event of allergic reactions, the drug should be cancelled and, if necessary, antihistamines and calcium preparations should be administered. In rare cases, tissue swelling at the injection site may occur, which resolves spontaneously within 1–2 days.

Interaction with other veterinary drugs:

Withdrawal period:

Milk for human consumption may only be taken after 10 days from the last treatment.Milk obtained before the established withdrawal period may be used for feeding animals after boiling.

Animals must not be slaughtered for human consumption within 28 days after the last treatment. Meat of animals forcibly slaughtered earlier than the specified period may be used for feeding carnivores.

Storage conditions:

Store in a dry, dark place at a temperature of 5º C to 25º C.

Shelf-life:

Shelf-life of the veterinary drug under appropriate storage conditions is 2 years from the date of manufacture. After the first opening of the vial – 28 days under proper storage conditions.