Ricobendazole 100

ветеринарный препарат рикобендазол 100

Veterinary drug RICOBENDAZOLE 100


Treatment of nematodes, cestodoses and trematodes in cattle, sheep and goats



  • Broad spectrum of antiparasitic activity

  • Only one injection is required

  • Ovocidal activity

  • High bioavailability and quick action

  • Allowed for use by milking animals and young animals

  • Allowed for use in the second third of pregnancy for cows

Therapeutic indications:

The drug is used in cattle, sheep and goats with nematodes, cestodes and trematodes.

Composition of the veterinary drug:

1 ml RICOBENDAZOLE 100 solution for injection contains:

  • 100 mg ricobendazole as an active substance;

Pharmacological activity:

The active substance of the veterinary drug is ricobendazole, anthelmintic belonging to the benzimidazole group. Ricobendazole has a wide spectrum of anthelmintic action. It is active against mature and larva nematodes (including genera: Dictyocaulus, Haemonchus, Ostertagia, Thelazia, Trichostrongylus, Nematodirus, Cooperia, OesophagostomumBunostomum, Chabertia, Trichocephalus), cestodes (including the genus Chaberostomus, Moniezia, Avitellinae, Thysaniezia), as well as mature trematodes (including genera: Fasciola, Paramphistomum, Dicrocoelium). Ricobendazole has an ovocidal effect, thereby reducing the infestation of pastures with helminth eggs.

The mechanism of anthelmintic activity of ricobendazole is based on the selective suppression of beta-tubulin polymerization, which leads to the destruction of cytoplasmic microtubules in cells of the helminths intestinal tract; suppresses the processes of transport and utilization of glucose and inhibits the synthesis of ATP, blocks the movement of secretory granules and other organelles in muscle cells of parasites, disrupting the permeability of cell membranes and muscle innervation, which causes paralysis and death of parasites. Ricobendazole also inhibits fumarate reductase, an enzyme involved in the energy metabolism of helminth cells.

After parenteral administration of the drug, ricobendazole is well absorbed and distributed in all organs and tissues of the body. The maximum concentration of the active substance in the blood is reached after 8 hours. Ricobendazole is metabolized in the liver to albendazole sulfone and other metabolic products. Metabolites are excreted mainly with bile, to a small extent - with urine, in lactating animals - partly with milk.

Dosage:

Deworming of animals is carried out as required, as well as in scheduled time in the spring before pasture and in the fall before stalling.
The drug is administered to animals once, intramuscularly or subcutaneously.

For cattle:

  • with moniesiasis, pulmonary and gastrointestinal nematodes at a dose of 1 ml of the drug per 25 kg of animal body weight (which corresponds to 4 mg of ricobendazole per 1 kg of animal body weight);
  • with trichocephalosis at a dose of 1 ml of the drug per 20 kg of animal body weight (which corresponds to 5 mg of ricobendazole per 1 kg of animal body weight);
  • with chronic fascioliasis, paramphistomatosis, dicroceliosis in a dose of 1 ml of the drug per 12.5 kg of animal body weight (which corresponds to 8 mg of ricobendazole per 1 kg of animal body weight).

For sheep and goats:

  • with moniesiasis, thysaniasis, avitellinosis, pulmonary and gastrointestinal nematodes, sheep - at a dose of 1 ml per 25 kg of animal body weight (which corresponds to 4 mg of ricobendazole per 1 kg of animal body weight), goats - at a dose of 1 ml per 20 kg body weight of the animal (which corresponds to 5 mg of ricobendazole per 1 kg of body weight of the animal);
  • for chronic fascioliasis, dicroceliosis, paramphistomatosis, trichocephalosis at a dose of 1 ml of the drug per 12.5 kg of animal body weight (which corresponds to 8 mg of ricobendazole per 1 kg of animal body weight).

When the drug is administered in a volume exceeding 5 ml for sheep and goats, 15 ml for cattle, injections should be carried out in several spots. In the cold season, the drug must be warmed up to a temperature of 20-25 ° C before administration.

Before mass treatments, each batch of the drug is preliminarily tested on a small group of animals (10-15 animals), which are monitored for 3 days. In the absence of complications, the drug is used for the entire livestock.

Precautions and adverse reactions:

When using the drug in accordance with this instruction, side effects and complications are generally not observed. If an allergic reaction occurs, the use of the drug is discontinued and antihistamines and calcium preparations are prescribed.

A contraindication to the drug use is the increased individual sensitivity of the animal to ricobendazole. It is forbidden to use the drug in case of acute fascioliasis, during the breeding period, in malnourished and sick animals.

Overdose symptoms are associated with the effect of the drug on the hematopoietic organs (leukopenia, granulocytopenia, agranulocytosis, thrombocytopenia) and liver function (increased activity of hepatic transaminases). The animal may have anorexia, motor discoordination, lethargy. In this case, the use of the drug is discontinued and symptomatic treatment is prescribed.

After the first administration and cancellation no peculiarities are revealed.

The drug must not be mixed in the same syringe with other veterinary drugs. It is forbidden to use the drug together with praziquantel, dexamethasone, as this will lead to an increase in the concentration of ricobendazole in the blood of the animal.

It is forbidden to use the drug for pregnant cows in the first third, for pregnant sheep - in the first half of pregnancy. The drug is approved for use in lactating animals. Use in young animals with caution, under the supervision of a veterinarian.

Withdrawal period:

Animals must not be slaughtered for human consumption within 30 days after the last treatment. Meat of animals forcibly slaughtered earlier than the specified period may be used for feeding carnivores. Milk for human consumption may only be taken after 5 days from the last treatment. Milk obtained earlier than the established period can be used after heat treatment for animal feed.

Storage conditions:

Store in a dark place at a temperature of +2° C to +25° C.

Shelf-life: 

Shelf-life of the veterinary drug under appropriate storage conditions is 2 years from the date of manufacture. Shelf-life after first opening: 28 days

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