Respiroflor-forte

Therapeutic indications:

The drug is used for therapeutic purposes in pigs for actinobacillus pleuropneumonia, Glässer’s disease (polyserositis), bordetellosis, pasteurellosis, mycoplasmosis, salmonellosis, escherichiosis (colibacillosis), and other bacterial infections caused by microorganisms sensitive to florfenicol.

Composition of the veterinary drug:

1 ml of the preparation contains:

• 200 mg of florfenicol
• 100 mg flunixin (flunixin meglumine) as an active substance.

Pharmacological activity:

The drug belongs to combined antibacterial agents.

Florfenicol, the active ingredient of the drug, has a broad spectrum of antibacterial activity against: Actinobacillus pleuropneumoniae, Pasteurella multocida, Mannheimia haemolytica, Bordetella bronchiseptica, Haemophilus parasuis, Mycoplasma hyopneumoniae, Mycoplasma hyorhinis, Ornithobacterium rhinotracheale, Escherichia coli, Salmonella spp., Staphylococcus aureus, Streptococcus spp., Klebsiella spp., Proteus spp.

Florfenicol exerts a bacteriostatic effect on susceptible microorganisms. In the bacterial cell protoplasm, florfenicol binds to the 70S ribosomal subunit and blocks the enzyme peptidyl transferase, that results in inhibition of protein synthesis at the ribosomal level.

When the drug is administered orally, florfenicol is well absorbed from the gastrointestinal tract and penetrates into all organs and tissues, but does not cross histohematic barriers. The bioavailability of florfenicol after oral administration is 88% in pigs. The maximum concentration of the antibiotic in the blood is reached within 1–2 hours. The therapeutic concentration of the antibiotic in organs and tissues is maintained for 24 hours. In pigs, florfenicol is eliminated primarily in the urine and to a lesser extent in the feces.

Flunixin, the active ingredient of the drug, is a non-steroidal anti‑inflammatory agent with pronounced analgesic and antipyretic effects. Flunixin is a non‑selective cyclooxygenase (COX1 and COX2) inhibitor that reduces the production of prostaglandin E2. The reduction in the production of this inflammatory mediator accounts for the analgesic, antipyretic, and anti‑inflammatory effects of flunixin.

When the drug is administered orally, flunixin is rapidly absorbed and penetrates into all organs and tissues. The maximum concentration in the blood is reached within 1–2 hours, and the therapeutic concentration in the organs and tissues of animals is maintained for 24 hours. Flunixin is 99% bound to plasma proteins and is eliminated from the animal body in feces (57%) and urine (34%).

Dosage:

The drug is administered orally with drinking water at a daily dose of 5 mg of florfenicol and 2.5 mg of flunixin per 1 kg of body weight, which corresponds to 1 mL of the drug per 40 kg of body weight, for 5–7 days.

Before use, the bottle/canister containing the drug should be shaken.

The drug may be administered using pulse dosing.

Depending on the watering regimen and the settings of the dosing equipment, either a treatment solution or a stock working suspension may be prepared.

To prepare the treatment solution, the drug must be diluted 200‑fold or more, as florfenicol dissolves in water at a concentration not exceeding 1 g/L, i.e., when diluting 1 L of the drug in 200 L of drinking water.

To prepare a stock working suspension for subsequent dosing, dissolution and administration using dosing devices (pulse dosing), the drug may be mixed with drinking water in any proportion, for example, 10 L of the drug with 10 L of water, 2 L of the drug with 50 L of water, or in other ratios. If necessary, the prepared stock working suspension should be stirred periodically (once every 2–6 hours).

The drug should be used immediately after preparing the treatment solution or stock working suspension and renewed every 24 hours throughout the course of treatment. During the therapy period, animals should receive only water containing the drug. If this is not possible, for example when using pulse dosing, the daily dose should be administered over at least 4 hours, or divided into two equal parts and administered at 12‑hour intervals.

Precautions and adverse reactions:

Side effects and complications when using the drug in accordance with these instructions are generally not observed. In animals with increased individual sensitivity to the components of the drug, allergic reactions (edema, itching, dermatitis) may occur. In such cases, the use of the drug is discontinued, and if necessary, antihistamines are administered and symptomatic treatment is provided.

The drug is contraindicated in animals with increased individual sensitivity to its components. Do not use in animals with renal or hepatic insufficiency.

In case of overdose, diarrhea, refusal of feed and water, perianal erythema, and edema may be observed. These symptoms resolve spontaneously without the need for symptomatic treatment.

The drug must not be used simultaneously with thiamphenicol, fluoroquinolones, penicillins, cephalosporins, as well as with other non‑steroidal anti‑inflammatory drugs or corticosteroids.

No specific effects have been observed upon first administration or upon discontinuation of the drug.

Avoid missing the next dose of the drug, as it may lead to the reduced therapeutic effect. If administration of the veterinary drug is missed, resume it in the same dosage and according to the same treatment scheme as soon as possible. Do not increase the dose to compensate the missing one.

Do not use in pregnant sows, sows during lactation, and in breeding boars.

Withdrawal period:

Pigs must not be slaughtered for human consumption before 14 days after the last drug administration. Meat of animals and poultry forcibly slaughtered earlier than the specified period expires may be used for feeding carnivores.

Storage conditions:

The drug should be stored in a dark place at a temperature between 2 °C to 25 °C. The drug should be kept out of reach of children.

Shelf-life:

Shelf-life of the veterinary drug is 2 years from the date of manufacture. Shelf-life after the first opening of the bottle is 28 days under appropriate storage conditions. The prepared working solution should be used within 24 hours. 

Available without prescription.