Marbofloxacin 100

Therapeutic indications:

The veterinary drug is used for the treatment of respiratory diseases (SRD) of bacterial etiology, metritis-mastitis-agalactia syndrome in pigs; in cattle - for the treatment of respiratory diseases (BRD) and mastitis caused by marbofloxacin-sensitive microorganisms.

Composition of the veterinary drug:

1 ml of the drug contains:

•          100 mg of marbofloxacin as an active substance.

Pharmacological activity:

The drug belongs to the antibacterial compounds of fluoroquinols group.

Marbofloxacin has a broad spectrum of antibacterial action. Marbofloxacin is highly effective against gram-positive and gram-negative microorganisms: Pasteurella multocida, Mannheimia haemolytica, Escherichia coli, Salmonella spp., Citrobacter freundii, Serratia marcescens, Morganella morganii, Mycoplasma spp., Proteus spp., Haemophilus spp., including Histophilus somni (Haemophilus somnus), Moraxella spp., Pseudomonas spp., Staphylococcus spp., Streptococcus spp. and so on.

The mechanism of action is based on the suppression of bacterial enzymes of DNA-girase and topoisomerase IV, participating in DNA replication of microorganisms.

After intramuscular or subcutaneous injection in cattle and pigs, the veterinary drug is quickly and fully absorbed. Marbofloxacin reaches its maximum concentration in plasma in less than 1 hour. It has high bioavailability – almost 100 %.

Marbofloxacin binds to plasma proteins to an insignificant extent. It is well-distributed in the tissues of most organs (liver, kidneys, skin, lungs, mammary gland, uterus), reaching a higher concentration then in plasma. The therapeutic concentration of marbofloxacin in the blood is maintained for 48 hours. Marbofloxacin is excreted from the animal organism in unchanged form with faeces and urine.

Dosage:

The drug is administered once per day (with an interval of 24 hours) in the following doses: 

• pigs - at a dose of 2 mg of the drug per 1 kg of body weight, which corresponds to 1 ml of marbofloxacin per 50 kg of body weight, for 3 days, via intramuscular injection;
• cattle - at a dose of 2 mg of the drug per 1 kg of body weight, which corresponds to 1 ml of marbofloxacin per 50 kg of body weight, for 3-5 days, via intramuscular or subcutaneous injection. In acute respiratory diseases a single intramuscular injection of the drug is recommended at a dose of 8 mg of marbofloxacin per 1 kg of animal body weight, which corresponds to 2 ml of the drug per 25 kg of animal body weight.

Due to the possible pain reaction during injection, the maximum volume of the drug per injection site should not exceed 20 ml.

Precautions and adverse reactions:

When using the drug in accordance with this instruction, side effects and complications are generally not observed.  Inflammatory reaction at the drug injection site is possible to occur.

Persistent allergic reactions may occur in animals with increased individual sensitivity to the drug components. In this case, if necessary, antihistamines are prescribed and symptomatic treatment is carried out.

Do not use in animals with hypersensitivity to the drug components.

In overdose of the veterinary drug, nervous system abnormalities (malfunctioning) may be observed in animals. In this case, the drug is canceled and, if necessary, symptomatic treatment is prescribed.

Do not use the drug simultaneously with antibiotics of tetracycline and macrolide groups, as well as with non-steroidal anti-inflammatory drugs.

After the first administration and cancellation, no peculiarities of the drug use have been revealed.

Avoid missing the next dose of the drug, as it may lead to the reduced therapeutic effect. If administration of the veterinary drug is missed, resume it in the same dosage and according to the same treatment scheme as soon as possible. Do not increase the dose to compensate the missing one.

The drug may be administered to pregnant and lactating females at a daily dose of 2 mg of marbofloxacin per 1 kg of animal body weight. Safety of drug administration to these groups of animals at a dose of 8 mg of marbofloxacin per 1 kg of animal body weight has not been established.

Withdrawal period:

Pigs must not be slaughtered for human consumption before 4 days after the last drug administration, cattle  -  6 day after the last drug administration. Meat of animals forcibly slaughtered before the specified period expires may be used for feeding carnivores.

Milk of dairy cows can be used for food purposes not earlier than 72 hours last drug administration.

Storage conditions:

Store in a dark place at a temperature between 2 °C to 25 °C.

Shelf-life:

Shelf-life of the veterinary drug under appropriate storage conditions is 3 years from the date of manufacture, after the first opening of the bottle (vial) - 28 days.