Enmitryl 100

Therapeutic indications:

Veterinary drug ENMITRYL 100 is used for treatment of cattle and pigs with respiratory infections, infections of gastrointestinal tract, genitourinary system, septicemia, bacterial and enzootic pneumonia, atrophic rhinitis, mastitis-metritis-agalactia syndrome, multi-infections, secondary infections in viral diseases and other diseases, the causative agents of which are sensitive to enrofloxacin.

Composition of the veterinary drug:

1 ml of ENMITRYL 100 contains 100 mg of enrofloxacin as an active substance.

Pharmacological activity:

The active substance of the veterinary drug is enrofloxacin, which is an antibiotic from the group of fluoroquinolones with a broad spectrum of bactericidal and antimycoplasmic activity.

Enrofloxacin is active against gram-positive and gram-negative microorganisms, such as Escherichia coli, Salmonella spp., Pasteurella multocida, Mannheimia haemolytica, Staphylococcus aureus, Staphylococcus hyicus, Streptococcus spp., Klebsiella spp., Pseudomonas aeruginosa, Bordetella bronchiseptica, Campylobacter spp., Corynebacterium pyogenes, Proteus spp., Mycoplasma spp., Brucella canis, Actinobacillus spp., Listeria monocytogenes, Haemophilus spp., Clostridium perfringens and others.

The mechanism of action of enrofloxacin is to inhibit the activity of the enzyme gyrase, which affects the replication of the DNA helix of the bacterial cell.

When administered parenterally, enrofloxacin is rapidly absorbed from the injection site and penetrates into most organs and tissues of the body. The maximum concentration of enrofloxacin in the blood is reached after 30–60 minutes, the therapeutic concentration is maintained for 72 hours after administration. Enrofloxacin is excreted from the body mainly unchanged and partly in the form of a metabolite - ciprofloxacin, mainly in urine and bile.

Dosage:

The drug is administered once to:

- cattle subcutaneously at a dose of 7.5 mg of enrofloxacin per 1 kg of animal body weight, which corresponds to 7.5 ml of the drug per 100 kg of animal body weight.

- pigs intramuscularly at a dose of 7.5 mg of enrofloxacin per 1 kg of animal body weight, which corresponds to 7.5 ml of the drug per 100 kg of animal body weight.

If necessary, administration of the drug is repeated after 72 hours.

Due to a possible painful reaction, the drug should not be injected into one site in cattle in a volume exceeding 15 ml, and in pigs in a volume exceeding 7.5 ml.

Precautions and adverse reactions:

When using the drug in accordance with this instruction, side effects and complications in animals generally are not observed. In some animals, after using the drug, a temporary dysfunction of the gastrointestinal tract (vomiting, diarrhea) is possible. Irritation may appear at the injection site, which resolving spontaneously. In animals with increased individual sensitivity to the components of the drug, allergic reactions may occur. In this case, if necessary, antihistamines are prescribed, symptomatic treatment is carried out.

Do not use the drug in animals with increased individual sensitivity to the components of the drug. Do not use the drug in case of heavy cartilage-related diseases; lesions of the nervous system, accompanied by convulsions; and also in the presence fluoroquinolone-resistant microorganisms.

In case of an overdose of the drug, the animal may experience a decrease in appetite, depression, vomiting, diarrhea. There is no specific antidote. In case of an overdose, use symptomatic treatment.

Do not use the drug simultaneously with amphenicols, macrolides, tetracyclines, theophylline and nonsteroidal anti-inflammatory drugs. Do not mix in one syringe with other medications.

The drug may be used in lactating and pregnant animals.

After the first administration and cancellation no peculiarities are revealed.

Withdrawal period:

Slaughter of animals for meat is allowed no earlier than 14 days after the last treatment. Meat of animals forcibly slaughtered earlier than the specified period may be used for feeding carnivores. Milk for human consumption may only be taken after 10 days from the last treatment. Before the expiration of the specified period, milk can be used after heat treatment for feeding animals.

Storage conditions:

Store in place protected from light at a temperature of 15 C⁰ to 25 C⁰.

Shelf-life:

Shelf life of the veterinary drug is 3 years from the date of production, after first opening of the bottle - 28 days.