Doxycycline-O

Therapeutic indications:

The drug is prescribed for therapeutic purposes in pigs and agricultural poultry (broilers, breeding poultry, parent stock poultry, replacement pullets) for bacterial respiratory and gastrointestinal diseases (colibacillosis, pasteurellosis, salmonellosis, mycoplasmosis, etc.) whose causative agents are sensitive to doxycycline.

Pharmacotherapeutic group:

Tetracyclines.

Dosage form description

Solution for oral administration. In appearance, the drug is a solution ranging from light yellow to dark brown in color.

1-liter polymer bottles and 5-liter canisters.

Composition of the veterinary drug:

1 ml of the drug contains 100 mg of doxycycline (as doxycycline hyclate) as the active substance.

Pharmacological activity:

Doxycycline, which is part of the drug, acts bacteriostatically on gram-positive and gram-negative microorganisms, certain protozoa, and mycoplasmas, including Escherichia coli, Haemophilus spp., Pasteurella spp., Salmonella spp., Staphylococcus spp., Streptococcus spp., Clostridium spp., Chlamydia spp., Listeria monocytogenes, Babesia spp., Plasmodium falciparum, Entamoeba histolytica, and other microorganisms sensitive to doxycycline.

Doxycycline inhibits protein synthesis in the microbial cell, disrupting the binding of aminoacyl-tRNA to the 30S ribosomal subunit. The action of doxycycline on protozoa is due to the blocking of protein synthesis in the apicoplast – specific binding of doxycycline to the 70S ribosomal subunit prevents the translation of proteins necessary for the parasite's development. Following administration, doxycycline is well absorbed in the gastrointestinal tract and rapidly distributed in most body organs and tissues. The maximum concentration in the blood is reached 2–4 hours after administration, and the therapeutic effect is maintained for 18–24 hours. Doxycycline undergoes minimal metabolism and is excreted from the body mainly with feces and urine.

Dosage:

The drug is used individually or in groups orally with drinking water in the following doses:

• for poultry: 0.5–1 ml of the drug per 1 liter of drinking water (corresponding to 50–100 mg of doxycycline per 1 liter of water or 1–2 ml of the drug per 10 kg of bird body weight) for 3–5 days;
• for pigs: 1 ml of the drug per 10 kg of animal body weight (corresponding to 10 mg of doxycycline per 1 kg of animal body weight or 0.5–1 liter of drug per 1 ton of water) for 5 days.

The aqueous solution of the drug is prepared daily in a volume calculated for consumption during the day. During the period of drug use, the prepared solution must be the sole source of drinking water for animals and poultry. To avoid the formation of resistant microorganism strains, the established periods of drug use should not be exceeded.

Contraindications:

The use of the drug is contraindicated in animals and poultry with hypersensitivity to the components of the drug, as well as with severe liver and kidney dysfunction.

Overdose:

In case of an overdose, animals and poultry may exhibit refusal of feed and depression. In this case, the drug is discontinued and, if necessary, symptomatic therapy is prescribed.

Pregnancy and lactation:

The use of the drug during pregnancy and lactation is prohibited.

Special indications:

No specific features of action upon the first use or discontinuation of the drug have been identified. Skipping a scheduled administration of the drug to animals and poultry should be avoided, as this may lead to a decrease in therapeutic efficacy. If a dose is missed, the course of administration must be resumed in accordance with the prescribed dose and treatment schedule. The missed dose should not be compensated by increasing the subsequent dose.

Side effects and individual intolerance:

Side effects and complications are generally not observed when the drug is used in accordance with this instruction. In animals and poultry with hypersensitivity to the components of the drug, allergic reactions may occur. In this case, use of the drug is discontinued, and antihistamines and symptomatic treatment are prescribed if necessary.

Withdrawal period:

Slaughter of animals and poultry for meat is permitted no earlier than 20 days after the last administration of the drug. In case of forced slaughter earlier than the specified period, the meat may be used as feed for carnivorous animals.

The use of the drug is prohibited in laying birds whose eggs are used for human food, as well as in replacement pullets less than 20 days before the onset of egg-laying.

Shelf-life:

2 years from the date of manufacture. The use of the drug after the expiration date is prohibited.

Storage conditions:

In a dry place protected from light at temperatures from 2 °C to 25 °C. The drug should be stored in a place out of the reach of children. After first opening of the bottle/canister – 28 days under appropriate storage conditions. The prepared solution is valid for 24 hours.