Amoxicillin-200

Therapeutic indications:

Veterinary drug Аmoxicillin-200 is used for calves, pigs and poultry (broilers, breeding poultry, poultry of the parent flock, replacement young chickens) with pasteurellosis, salmonellosis, clostridiosis, colibacteriosis, infectious atrophic rhinitis and erysipelas of pigs, as well as other bacterial diseases of the gastrointestinal and respiratory tracts, genitourinary system caused by pathogens sensitive to amoxicillin.

Composition of the veterinary drug:

1 g of Аmoxicillin-200 powder contains:

• 200 mg Amoxicillin trihydrate

Pharmacological activity:

The active substance of the veterinary drug is amoxicillin, which is a semi-synthetic antibiotic from the penicillin group with a broad spectrum of bactericidal activity. Following pathogens are sensitive to amoxicillin: Staphylococcus spp., Erysipelothrix rhusiopathiae, Corynebacterium spp., Clostridium spp., Campylobacter spp., Brucella spp., Salmonella spp., Haemophilus spp., Bacteroides spp., Fusobacterium necrophorum, Proteus spp., Streptococcus spp., Listeria monocytogenes, Actinomyces spp., Pasteurella spp. etc., excluding strains producing β-lactamase.

The mechanism of bactericidal activity is based on the on the blocking of the synthesis of the bacterial cell wall by inhibiting transpeptidase and carboxypeptidase, which leads to disruption of the osmotic balance and destruction of the bacterial cell.

After oral administration of the drug, amoxicillin is well absorbed from the gastrointestinal tract and penetrates into all organs and tissues of the body, where it remains in therapeutic concentrations for 24 hours. Amoxicillin is excreted from the body mainly unchanged in the urine, in a small amount - with bile, in lactating females - with milk.

Dosage:

The drug is administered to animals and poultry orally mixed with feed in the following doses:

• calves 50–75 mg of the drug per 1 kg of animal body weight, which corresponds to 10–15 mg of amoxicillin trihydrate per 1 kg of animal body weight, for 10–14 days;
• pigs 1–1.5 kg of the drug per 1 ton of feed, which corresponds to 50–100 mg of the drug per 1 kg of animal body weight or 10–20 mg of amoxicillin trihydrate per 1 kg of animal body weight, for 10–14 days;
• poultry 1 kg of the drug per 1 ton of feed, which corresponds to 100 mg of the drug per 1 kg of bird body weight or 20 mg of amoxicillin trihydrate per 1 kg of bird body weight, for 5–7 days.

The drug is thermostable, does not lose its properties during heat treatment at a temperature of 100 °C. 

 Precautions and adverse reactions:

When using the drug in accordance with this instruction, side effects and complications generally are not observed. In case of increased individual sensitivity to β-lactam antibiotics, allergic reactions (skin rash, erythema, itching) are possible, in piglets - swelling of the rectum, with prolonged use - dysbacteriosis. With the manifestation of side effects, the the drug is cancelled, antihistamines and calcium preparations are prescribed.

Do not use in animals and poultry which are known to be hypersensitive to penicillins and cephalosporins, as well as in case of impaired renal excretory function. Do not use the drug to replacement young chickens less than 2 weeks before the start of egg laying and to ruminants older than 6 months of age.

In case of the overdose of the veterinary drug, vomiting and diarrhea may occur. In this case, the drug is canceled and, if necessary, symptomatic treatment is prescribed.

Do not use simultaneously with antibiotics from groups of tetracycline, macrolides, lincosamides, sulfonamides and amphenicols.

Аfter the first administration and cancellation no special aspects are revealed.

Avoid missing scheduled administration of the Аmoxicillin-200 as it may lead to a decrease of therapeutic efficacy. If administration of the veterinary drug is missed, resume it in the same dosage according to the same scheme. Do not offset the missed dose by increasing the next one.

Do not use for poultry, whose eggs are used for human consumption.

Withdrawal period:

Animals and poultry must not be slaughtered for human consumption within 15 days after the last treatment. Meat of animals forcibly slaughtered earlier than the specified period may be used for feeding carnivores.

Storage conditions:

Store in a dark place at a temperature of +2 °C to +25 °C.  Keep out of reach of children.

Shelf-life:

Shelf-life of the veterinary drug under appropriate storage conditions is 3 years from the date of manufacture. Shelf-life after first opening: 3 months.