Tiamullinum

Therapeutic indications:

The drug is used for the treatment of infectious diseases caused by pathogens sensitive to thiamulin in pigs and poultry (broiler chickens, repair young laying hens, turkeys and ducklings). The drug is prescribed to pigs in case of dysentery, enzootic pneumonia and actinobacillosis pleuropneumonia, gastroenterocolitis of bacterial etiology; to poultry –  in case of infections caused by Mycoplasma gallisepticum, Mycoplasma synoviae, Mycoplasma meleagridis.

Composition of the veterinary drug:

1 g of the drug contains:

• 0.45 g of tiamulin hydrogen fumarate

Pharmacological activity:

TIAMULLINUM is an antibacterial drug. Tiamulin hydrogen fumarate, which is the active substance of the drug, is a semisynthetic antibacterial compound of the pleuromutilin group.

Tiamulin has bacteriostatic activity against gram-positive and gram-negative microorganisms: Haemophilus spp., Treponema hyodysenteriae, Staphylococcus spp., Streptococcus spp., Clostridium perfringens, Leptospira spp., Listeria monteocytogenens, Leptospira spp., Listeria monteocytogenens and Rubbishlasma spp. Does not have a detrimental effect on bacteria of the Enterobacteriaceae family (Salmonella spp. and Escherichia coli).

Tiamulin binds to the 50S ribosomal subunit that leads to the inhibition of the protein biosynthesis in the microbial cell.

Being administered orally, the antibiotic is well absorbed from the gastrointestinal tract and distributed in organs and tissues. Maximum concentration of tiamulin in the organism is reached after 2 hours after the drug administrartion in pigs; in poultry - after 4 hours.

Tiamulin is excreted from the body mainly with faeces.

Dosage:

The drug is administered orally individually or in groups, mixed with food or water, once a day, for 3-5 days, in the following doses:

• in pigs: 0.6–1 g of the drug per 100 kg of animal body weight (which corresponds to 3–4.5 mg of tiamulin hydrogen fumarate per 1 kg of animal body weight) or mix 200–450 g of the drug with 1 ton of feed. For the treatment of pigs with enzootic pneumonia, mycoplasma arthritis and dysentery, 1 kg of the drug is dissolved in 5-6.5 tons of water;
• in poultry (broiler chickens, replacement pullets, turkey poults and ducklings): 25-50 mg of the drug per 1 kg of body weight of a bird (which corresponds to 11-23 mg of tiamulin hydrogen fumarate per 1 kg of body weight of a bird) or 1 kg of the drug for 2-3.5 tons of drinking water.

During the treatment period, pigs and birds should receive only water containing the drug.

The prepared working solution of the drug must be used within 24 hours. To ensure uniform distribution of the drug in the feed, use 2–3-stage mixing. The preparation mixed with feed must be used within 10 days.

The drug is thermostable, does not lose its properties during heat treatment for 15 minutes at a temperature of 100 ° C.

Precautions and adverse reactions:

If used in accordance with the instructions, the drug usually does not cause side effects. In rare cases (with increased individual sensitivity), animals and poultry may experience allergic reactions (dermatitis, itching, edema) and indigestion. In this case, the use of the drug is discontinued and antihistamines are prescribed.

Do not use the drug in pigs and poultry with increased individual sensitivity to the components of the drug, as well as with severe liver and kidney dysfunctions.

In case of an overdose of the drug, diarrhea, anorexia, and nephrotoxic effects may occur. In this case, the use of the drug is discontinued and symptomatic treatment is prescribed.

Do not use the drug simultaneously with monensin, narazin and salinomycin and for 7 days before or after the use of the drugs containing these substances.

After the first administration no peculiarities are revealed.

Avoid missing the next dose of the drug, as it may lead to the reduced therapeutic effect. If administration of the veterinary drug is missed, resume it in the same dosage and according to the same treatment scheme as soon as possible.

The drug should not be used for pregnant sows in the first stage of pregnancy (during the first month), for breeding boars and laying hens during laying. It is not recommended to use the drug in lactating animals. The decision on using the drug during pregnancy and lactation is taken by the veterinarian based on an benefit-risk evaluation.

Withdrawal period:

Pigs should not be slaughtered for human consumption within 10 days after the last drug treatment, poultry - within 7 days after the last drug treatment. Meat of animals and poultry forcibly slaughtered earlier than the specified period expires may be used for feeding carnivores.

Storage conditions:

Store in a dry, dark place at a temperature between +2°C to +25°C.

The drug should be kept out of the reach of children.

Shelf-life:

Shelf-life of the veterinary drug under appropriate storage conditions is 2 years from the date of manufacture, after the first opening of the package - 28 days. The shelf-life of the working solution is 24 hours.