Retsefur PS-100

Veterinary drug RETSEFUR PS-100


For the treatment of respiratory, gastrointestinal and gynecological diseases in pigs



  • Highly effective against a broad spectrum of pathogenic microorganisms

  • Only one injection is required

  • A long-acting drug (the therapeutic concentration is maintained up to 7 days since the drug administration)

  • Optimal dosage for pigs


Therapeutic indications:

The drug is used in pigs for the treatment of respiratory and gastrointestinal diseases, metritis-mastitis-agalactia syndrome and other diseases caused by ceftiofur-sensitive microorganisms.

Composition of the veterinary drug:

1 ml of the drug contains:

•             100 mg of ceftiofur crystalline-free acid as an active substance.

Pharmacological activity:

Ceftiofur, the active substance of the drug, is an antibiotic of the cephalosporin group. Ceftiofur has a broad spectrum of action against gram-positive and gram-negative bacteria, including Streptococcus spp., Actinomyces pyogenes, Staphylococcus spp., Salmonella spp., Escherichia coli, Pasteurella spp., Haemophilus spp., Actinobacillus pleuropneumoniae, Klebsiella spp., Citrobacter spp., Enterobacter spp., Bacillus spp., Proteus spp., Fusobacterium necrophorum and Bacteroides melaninogenicus (Porphyromonas asaccharolytica), including strains producing lactamase.

Ceftiofur inhibits the enzyme transpeptidase and suppresses the synthesis of mucopeptide (murein), peptidoglycan of the cell wall, that leads to the impaired growth of the microorganism’s cell wall and bacteria lysis.

After the drug administrartion, ceftiofur is rapidly metabolized to form desfuroylceftiofur, which has bactericidal activity equivalent to ceftiofur.  This active metabolite reversibly binds to proteins and is accumulated in the tissues affected by the pathogen. The maximum concentration of ceftiofur and its metabolites in the blood is reached in 22 hours and is maintained at a therapeutic level for up to 7 days from the moment of the drug administration.  Ceftiofur and its metabolites are excreted from the animal body mainly with urine.

Dosage:

The drug is administered to pigs via intramuscular injection at a dose of 1.0 ml of the drug per 20 kg of body weight, which corresponds to 5 mg of ceftiofur per 1 kg of body weight. Do not inject more than 4.0 ml per one injection site.  Before using flask with the drug should be shaken thoroughly until a homogeneous suspension is obtained.

Precautions and adverse reactions:

When the drug is used in recommended doses and in accordance with all the instructions, side effects and complications are generally not observed. Sometimes, in case of an overdose, side effects such as an inflammatory reaction and alopecia area at the injection site may be observed. These symptoms disappear naturally within 55 days.

Symptoms of overdose are not found.

Do not use in animals with hypersensitivity to β-lactam antibiotics. If symptoms of an allergic reaction occur, the drug should be cancelled; antihistamines, preparations with calcium should be prescribed.

Do not use the drug simultaneously with tetracycline, macrolide, lincosamide antibiotics. Do not mix with other drugs in the same syringe. 

The drug is used in pregnant and lactating sows under the supervision of a veterinarian.

Withdrawal period:

Pigs should not be slaughtered for human consumption within 71 days after the last drug treatment. Meat of animals forcibly slaughtered earlier than the specified period expires may be used for feeding carnivores.

Storage conditions:

Store in a dark place at a temperature between + 2 ° C to + 25 ° C. The drug should be kept out of the reach of children.

Shelf-life:

Shelf-life of the veterinary drug is 2 years from the date of manufacture. Shelf-life after the first opening of the vial is 28 days under appropriate storage conditions. Do not use the drug after the expiry date.

Создание сайтов в Минске - Aliva.by