Veterinary drug LINKOFERON-B solution
The drug is used in calves for the treatment of infectious diseases of bacterial and mixed (bacterial-viral) etiology, including but not limited to enzootic pneumonia, actinomycosis, septicemia, infectious polyarthritis, abscesses, otitis, purulent dermatitis, respiratory diseases (CRD) and other diseases caused by lincomycin-sensitive microorganisms resistant to penicillins and other antibiotics.
The drug is also used in sick animals for the treatment and prevention of mixed (bacterial-viral) diseases, when the risk of additional viral infections is high.
Composition of the veterinary drug:
1,0 ml of the drug contains:
• 0.1 g of lincomycin hydrochloride,
• not less than 10 000 IU / ml of antiviral activity of recombinant bovine interferon (IBR) protein
The drug has antimicrobial activity against most gram-positive aerobic and anaerobic lincomycin-sensitive microorganisms, including: Streptococcus spp., Staphylococcus spp., Bacillus spp., Corynebacterium spp., Actinomyces spp., Bacteroides spp., Clostridium spp., as well as Mycoplasma spp.
The mechanism of action of lincomycin hydrochloride is based on the suppression of protein synthesis of the microbial cell. Recombinant bovine interferon (IBR) is the second active substance of the drug. IBR has a significant immunostimulating activity with a species-specific mechanism in cattle. IBR enhances the antibiotic effect, increases nonspecific resistance of the organism to DNA and RNA-containing viruses and protects the organism from their negative effect. Interferon eliminates the immunosuppressive effects of the antibiotic.
After intramuscular administration, the drug is quickly and fully absorbed. A therapeutic concentration in the blood is reached in half an hour or in an hour after the injection of antibacterial activity and after 6 hours - immunomodulatory activity.
The maximum concentration of lincomycin in the blood is reached in 20-40 minutes after the drug administration and it is maintained for 3-6 hours. The therapeutic concentration of lincomycin in the blood is maintained for 24 hours. The immunostimulating activity of interferon reaches its maximum value in 12 hours and lasts for the next 24-30 hours.
Lincomycin does not undergo biotransformation in the body and is excreted unchanged mainly with the urine and bile.
The drug is administered intramuscularly at a dose of 1.0 ml per 10 kg of body weight every 24 hours for 3-5 days. Do not mix with other drugs in the same syringe.
Precautions and adverse reactions:
The use of the drug in combination with penicillins, cephalosporins, chloramphenicol or erythromycin may lead to antimicrobial antagonism. The use of the drug in combination with aminoglycosides - to synergistic action.
Do not use the drug simultaneously with barbiturates, kanamycin, ampicillin, novobiocin, heparin, calcium gluconate, theophylline and magnesium sulfate.
Do not use in animals with hypersensitivity to lincomycin, as well as with severe liver and kidney dysfunction.
Do not use in animals with strong ruminal digestion that are 6 months of age or older.
Animals must not be slaughtered for human consumption before 4 days after the last drug administration. Meat of animals forcibly slaughtered before the specified period expires may be used for feeding carnivores.
Store in a dry, dark place at a temperature between + 4 ° C to + 10 ° C.
Shelf-life of the veterinary drug is 18 months from the date of manufacture. Shelf-life after the first opening of the bottle is 3 days under appropriate storage and sterile conditions.