Recombinant swine interferon (ISR)

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Veterinary drug RECOMBINANT SWINE INTERFERON (ISR)


The drug is used for the treatment and prevention of infectious diseases in pigs



  • A highly effective drug due to species-specific mechanism of action

  • Antiviral, antibacterial and immunomodulatory effects

  • Significantly enhances the biological activity of vaccines and sera

  • Adaptogenic properties

  • No complications and side effects

  • No withdrawal period for animal products


Therapeutic indications:

The veterinary drug is used for the treatment and prevention of gastrointestinal and acute respiratory diseases (SRD) of viral and bacterial-viral etiology in pigs. The drug is also used as an immunostimulating agent when immunodeficiency conditions occur (poor cattle management, imbalanced feeding and so on).

Composition of the veterinary drug:

1 ml of the veterinary drug contains:

•          At least 10 000 IU of antiviral activity of recombinant porcine interferon (IPR).

Pharmacological activity:

Recombinant swine interferon (ISR) exhibits antiviral and immunostimulatory activity in piglets, young and adult pigs, but also indirectly affects the fetus when used in pregnant sows.

The therapeutic action of the drug is determined by the multiple effect of the exogenous protein directly on the virus infected cells. The drug contributes to the rapid induction of the endogenous interferon system, cellular and humoral immunity.

ISR acts as an inducer of the serum bactericidal activity. The drug also has anti-inflammatory effect. The veterinary drug increases the resistance of the animal organism to DNA and RNA-containing viruses and pathogenic microorganisms.

Dosage:

The drug is administered intramuscularly or subcutaneously at a dose of 1 ml per 10 kg of body weight.

For preventive purposes the drug is administered twice with an interval of 48 hours at a dose corresponding to the body weight of the animal:

•          in the first days after parturition,

•          in case of group housing,

•          imbalanced feeding,

•          during transportation,

•          risk of viral infections, etc.

The drug is administered to pregnant sows twice prior to parturition with an interval of 48 hours. In case of retarded parturition, the drug is administered again after 48 hours since the last injection.

To enhance the action of vaccines (antibacterial and inactivated viral) and sera, the drug is given at a single dose of 1 ml per 10 kg of body weight 48 hours prior to the vaccination.

For therapeutic purposes, 3 or 5 injections of the drug are administered with an interval of 48 hours. The drug is most effective in the early stages of disease.

In case of mixed bacterial-viral infections, the drug is given in combination with antibiotics, chemotherapeutic agents. Do not mix with antibacterial drugs in the same syringe. Do not inject in the same site with an antibacterial drug.

Follow the rules of personal hygiene and safety while handling the drug.

Precautions and adverse reactions:

When used in accordance with this instruction, side effects and complications are generally not observed.

There are no contraindications for the use of the drug.

Withdrawal period:

Meat may be used for human consumption without any restrictions after the last drug administration.  When prescribed together with antimicrobial drugs, estimate the withdrawal period for animal products in accordance with the antimicrobial drug prescriptions.

Storage conditions:

The drug should be stored in a dry, cool, dark place at a temperature between + 4 °C to + 10 °C.

The drug should be kept out of reach of children.

Shelf-life:

Shelf-life of the veterinary drug is 18 months from the date of manufacture. Shelf-life after the first opening is 28 days.

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