Veterinary drug GENTAFERON-B solution
GENTAFERON-B solution is used in calves and adult cattle for the treatment of infectious diseases of bacterial and mixed (bacterial-viral) etiology; diseases of the respiratory, urinary and gastrointestinal tracts; peritonitis, polyarthritis, dermatitis, wound infection, endometritis and other diseases caused by sensitive to gentamicin sulfate microorganisms.
The drug is used in sick animals for the treatment and prevention of multi-infection (bacterial and viral) diseases when risk of additional viral infection is high.
Composition of the veterinary drug:
1 ml of the drug contains:
• 0.04 g of gentamicin sulfate,
• At least 10 000 IU/ml of antiviral activity of recombinant bovine interferon (IBR) protein.
GENTAFERON-B solution has a broad spectrum of antibacterial action due to the presence in the solution of antibiotic gentamicin sulfate (GS), which is active against some gram-positive and most gram-negative microorganisms, including Escherichia coli, Enterobaster spp., Klebsiella spp., Salmonella spp., Pasteurella spp., Pseudomonas aeruginosa, Campylobacter spp., Proteus spp.
Gentamicin sulfate (GS) is a broad-spectrum bactericidal antibiotic of the aminoglycoside group. Gentamicin sulfate binds to the 30S subunit of bacterial ribosomes and inhibits the synthesis of the pathogen protein, preventing the formation of the transfer ribonucleic acid (tRNA) and information ribonucleic acid (mRNA) complex, that leads to the misreading of RNA and the formation of non-functional proteins.
Gentamicin sulfate has a bactericidal effect. In high concentrations it suppresses barrier functions of cytoplasmic membranes, that leads to the death of pathogen microorganisms.
Exogenous protein of recombinant bovine interferon is the active substance of the drug; after the injection, protein affects the virus infected cells and contributes to the rapid induction of the endogenous interferon system, cellular and humoral immunity.
Also exogenous protein has anti-inflammatory effect and increases the resistance of the animal organism to DNA and RNA-containing viruses and pathogenic microorganisms.
Once administered via intramuscular injection, gentamicin is quickly and fully absorbed. The maximum concentration of gentamicin is reached in the blood in an hour after the drug administration. Its therapeutic effect in the organism is maintained for 8-12 hours. Gentamicin penetrates into the pleural and abdominal cavities as well as cross the placenta. It is excreted from the body mainly in its active form through the kidneys.
GENTAFERON-B solution is injected intramuscularly at a dose of 1 ml per 10 kg of body weight every 12 hours for 5-7 days. In case of large volumes of the drug administration, the drug should be injected at several injection sites.
The drug should not be diluted with water or aqueous solutions. Do not mix with other drugs in the same syringe.
Precautions and adverse reactions:
Do not use the drug simultaneously with nephrotoxic antibiotics. Do not use in animals with hypersensitivity to gentamicin.
Do not use the drug 24 hours before and 24 hours after xylozine administration to avoid disorders of the nerve conduction (NC) (muscle relaxant action).
Animals must not be slaughtered for human consumption before 21 days after the last drug administration. Meat of animals forcibly slaughtered before the specified period expires may be used for feeding fur-bearing animals.
It is forbidden to use milk for human consumption during the treatment period and within 72 hours after the last drug administration. Milk obtained before the expiry of the established period is allowed for animal feeding.
Store in a dry, dark place at a temperature between + 4 °C to + 10 °C.
Shelf-life of the veterinary drug is 18 months from the date of manufacture.